INT227339

Context Info Confidence 0.28 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 4.08 Pain Relevance 0.31

extracellular space (TNF, Ins1) extracellular region (TNF, Ins1) intracellular (TNF) carbohydrate metabolic process (Ins1) extracellular matrix organization (TNF) cytoplasm (Ins1)

Anatomy Link Frequency Macrophages 1 monocytes 1 TNF (Homo sapiens) Ins1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 75 88.52 cytokine 22 61.36 metalloproteinase 64 5.00 tolerance 16 5.00 chemokine 8 5.00 anesthesia 7 5.00 Inflammatory response 6 5.00 Central nervous system 2 5.00 tramadol 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 95 100.00 Apoptosis 30 97.44 Obesity 288 95.72 Fatty Liver 11 93.36 INFLAMMATION 81 88.52 Body Weight 19 86.52 Diabetes Mellitus 15 85.08 Metabolic Syndrome 39 83.12 Necrosis 5 52.44 Atherosclerosis 8 52.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Insulin resistance appeared in association with fatty infiltration and TNF-?

TNF Spec (appeared) Binding (association) of Insulin associated with insulin resistance

1) Confidence 0.28 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266061 Disease Relevance 1.53 Pain Relevance 0

Macrophages and monocytes have been shown to respond to insulin with increased phagocytosis and glucose metabolism [15] and with increased TNF-?

TNF Binding (respond) of insulin in Macrophages

2) Confidence 0.04 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.28 Pain Relevance 0.15

Macrophages and monocytes have been shown to respond to insulin with increased phagocytosis and glucose metabolism [15] and with increased TNF-?

TNF Binding (respond) of insulin in monocytes

3) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.28 Pain Relevance 0.15

General Comments

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