INT227426

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Apex1) mitochondrion (Apex1) lyase activity (Apex1)
aging (Apex1) endoplasmic reticulum (Apex1) intracellular (Apex1)
Anatomy Link Frequency
lung 1
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 81 77.80 Quite High
Inflammation 108 77.12 Quite High
Inflammatory mediators 45 68.04 Quite High
dexamethasone 9 16.68 Low Low
Catecholamine 3 13.92 Low Low
cytokine 69 12.12 Low Low
cINOD 15 9.24 Low Low
vagus nerve 18 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 12 99.14 Very High Very High Very High
Sepsis 297 97.06 Very High Very High Very High
Thrombocytopenia 3 93.64 High High
Coagulation Disorder 9 90.04 High High
INFLAMMATION 249 77.44 Quite High
Disease 42 76.08 Quite High
Infection 54 73.52 Quite High
Autoimmune Disease 3 72.56 Quite High
Lung Injury 6 61.04 Quite High
Disseminated Intravascular Coagulation 3 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although antithrombin III failed to reduce mortality rate in a large sepsis clinical
           trial (Ref. 40), a recent study suggested that
           antithrombin III could attenuate endotoxin-induced systemic HMGB1 accumulation, and
           reduced endotoxaemic lethality (Ref. 111). 
Positive_regulation (accumulation) of Ref associated with sepsis
1) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.57 Pain Relevance 0.09
In a large clinical trial, human recombinant
         activated protein C (drotrecogin alfa) reduced 28-day mortality (from 30.8% in the placebo
         group to 24.7% in the experimental group) (Ref. 38), but was accompanied by a 1.5% increase in haemorrhagic complication risk
         (Ref. 38). 
Positive_regulation (increase) of Ref
2) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.48 Pain Relevance 0.03
Intriguingly, danaparoid sodium effectively protected
           rats against endotoxin-induced acute lung injury by attenuating systemic HMGB1
           accumulation (Ref. 113).


Positive_regulation (accumulation) of Ref in lung associated with adult respiratory distress syndrome
3) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.93 Pain Relevance 0.11
Another possibility might be increased nuclease activity during storage due to temperature changes or other unidentified technical problems.
Positive_regulation (increased) of nuclease
4) Confidence 0.01 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0

General Comments

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