INT22782

Context Info Confidence 0.81 First Reported 1981 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 25 Total Number 25 Disease Relevance 14.44 Pain Relevance 7.34

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)

Anatomy Link Frequency pancreas 3 eosinophil 2 jejunum 1 cleavage 1 acinar cells 1 PRSS1 (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 19 100.00 Chronic pancreatitis 75 99.88 spastic colon 55 99.64 tetrodotoxin 1 99.40 Inflammation 33 99.08 Enkephalin 6 99.00 Pain 68 97.32 alcohol 5 96.84 Neuropeptide 8 95.76 Spinal cord 1 92.48

Disease Link Frequency Relevance Heat Pancreatitis 428 99.92 Hypercalcemia 48 99.86 Inflammatory Bowel Disease 37 99.80 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 55 99.64 Multiple Organ Failure 1 99.40 INFLAMMATION 41 99.08 Disease 66 98.64 Ulcers 1 98.46 Necrosis 14 98.44 Disseminated Intravascular Coagulation 3 98.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemical localization of trypsinogen and trypsin in acute and chronic pancreatitis.

Localization (localization) of trypsin associated with chronic pancreatitis

1) Confidence 0.81 Published 1983 Journal Digestion Section Title Doc Link 6350076 Disease Relevance 0.35 Pain Relevance 0.26

Immunohistochemical localization of trypsinogen and trypsin in acute and chronic pancreatitis.

Localization (localization) of trypsinogen associated with chronic pancreatitis

2) Confidence 0.81 Published 1983 Journal Digestion Section Title Doc Link 6350076 Disease Relevance 0.35 Pain Relevance 0.26

Immunoreactive trypsin was localized with the peroxidase-antiperoxidase technique in normal human pancreatic tissue and in the glands of patients suffering from acute or chronic pancreatitis.

Localization (localized) of trypsin in glands associated with chronic pancreatitis

3) Confidence 0.81 Published 1983 Journal Digestion Section Abstract Doc Link 6350076 Disease Relevance 0.29 Pain Relevance 0.22

In chronic pancreatitis, the localization of trypsin in acinar cells was similar to that in normal pancreas.

Localization (localization) of trypsin in acinar cells associated with chronic pancreatitis

4) Confidence 0.81 Published 1983 Journal Digestion Section Abstract Doc Link 6350076 Disease Relevance 0.34 Pain Relevance 0.26

Increased interdigestive pancreatic trypsin secretion in alcoholic pancreatic disease.

Localization (secretion) of trypsin associated with pancreatitis

5) Confidence 0.80 Published 1985 Journal Dig. Dis. Sci. Section Title Doc Link 3987476 Disease Relevance 0.46 Pain Relevance 0.12

A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].

Localization (secreted) of trypsinogen in pancreas associated with chronic pancreatitis

6) Confidence 0.78 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10

To date, only a few cases have demonstrated that pancreatitis is caused by simultaneous CFTR and SPINK1 mutations (5.5%), of PRSS1 and SPINK1 (1.3%), and of PRSS1 and CFTR (1.8%).

Localization (caused) of PRSS1 associated with pancreatitis

7) Confidence 0.75 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2970583 Disease Relevance 0.49 Pain Relevance 0.09

Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitis.

Localization (screening) of trypsinogen gene associated with chronic pancreatitis

8) Confidence 0.74 Published 2001 Journal Clin. Genet. Section Title Doc Link 11260229 Disease Relevance 0.73 Pain Relevance 0.42

A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].

Localization (secreted) of trypsin in pancreas associated with chronic pancreatitis

9) Confidence 0.73 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10

The correlation was first observed in patients with hyperparathyroidism while trypsin activation, secretion stimulus and stabilization are suspected mechanisms [16].

Localization (secretion) of trypsin associated with hypercalcemia

10) Confidence 0.68 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.31 Pain Relevance 0.67

Augmentation of trypsin secretion was the most pronounced.

Localization (secretion) of trypsin

11) Confidence 0.53 Published 1981 Journal Digestion Section Abstract Doc Link 6260564 Disease Relevance 0.17 Pain Relevance 0.20

One drop of a 1 mg/ml CCK-OP solution applied intranasally, three times daily during 3 weeks resulted in a significant increase in volume, trypsin, lipase and amylase secretion in response to the Lundh test meal.

Localization (secretion) of trypsin

12) Confidence 0.46 Published 1981 Journal Digestion Section Abstract Doc Link 6260564 Disease Relevance 0.17 Pain Relevance 0.21

Measurement of the pancreatic response to feeding showed a 90% reduction in enzyme secretion compared to healthy volunteers, but no change in the uptake of stable isotope labeled amino acids into secreted trypsin.

Localization (secreted) of trypsin

13) Confidence 0.25 Published 2003 Journal Clin. Gastroenterol. Hepatol. Section Abstract Doc Link 15017674 Disease Relevance 0.80 Pain Relevance 0.22

Furthermore, trypsin-induced secretion was inhibited by the Ca(2+)-ATPase inhibitor cyclopiazonic acid and in low-Ca(2+) buffer.

Localization (secretion) of trypsin

14) Confidence 0.23 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.46 Pain Relevance 0.30

Another study demonstrated that trypsin secretion in AP patients, especially with necrotizing AP, is significantly suppressed compared to healthy individuals.

Localization (secretion) of trypsin associated with pancreatitis

15) Confidence 0.15 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.76 Pain Relevance 0

Commercial enzymes (trypsin, carboxypeptidase B) were used to release methionine- and leucine-enkephalin from precursors.

Localization (release) of trypsin associated with enkephalin

16) Confidence 0.15 Published 1990 Journal J. Chromatogr. Section Abstract Doc Link 2329143 Disease Relevance 0 Pain Relevance 0.92

A more recent study in healthy volunteers showed that EN can be given without stimulating pancreatic trypsin secretion provided that it is delivered into the mid-distal jejunum [31].

Localization (secretion) of trypsin in jejunum

17) Confidence 0.14 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0 Pain Relevance 0

As already mentioned, the pancreas is in a state of unresponsiveness during an attack of AP and the secretion of pancreatic juice and trypsin is reduced during AP [34, 37].

Localization (secretion) of trypsin in pancreas associated with pancreatitis

18) Confidence 0.13 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.92 Pain Relevance 0.15

Urinary trypsin inhibitor exists naturally in the human body and is secreted in greater quantities during stressful conditions, such as inflammation, cancer, infection, and tissue damage [15].

Localization (secreted) of trypsin in body associated with inflammation, cancer and infection

19) Confidence 0.12 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 1.24 Pain Relevance 0.33

Search parameters were as follows: cleavage by trypsin, one missed cleavage site allowed, carbamidomethylcysteine as fixed modification, and oxidized methionine as optional modification.

Localization (cleavage) of trypsin in cleavage

20) Confidence 0.04 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2716719 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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