INT227831

Context Info Confidence 0.07 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2) helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)

ERCC2 (Homo sapiens) PGBD3 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate receptor 2 5.00 anesthesia 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Repression 1 95.20 Genomic Instability 1 74.68 Infection 3 55.20 Cockayne Syndrome 55 5.00 Contagious Ecthyma 6 5.00 Hutchinson-gilford Progeria Syndrome 4 5.00 Disease 4 5.00 Syndrome 3 5.00 Aging 2 5.00 Freckles 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CSB binds to several TFIIH subunits including XPD [17], suggesting a possible role for the N-terminal CSB domain of the CSB-PGBD3 fusion protein in silencing PGBD3 family elements.

XPD Binding (binds) of PGBD3

1) Confidence 0.07 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.23 Pain Relevance 0

General Comments

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