INT227905

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL10, TIMP1) extracellular space (IL10) aging (TIMP1)
intracellular (IL10) cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
cartilage 2
IL10 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 84.68 Quite High
Osteoarthritis 37 83.20 Quite High
metalloproteinase 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Tendonitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 36 83.20 Quite High
Injury 2 76.20 Quite High
Osteoarthritis 12 55.64 Quite High
Shock 5 50.00 Quite Low
Necrosis 2 50.00 Quite Low
Cancer 1 50.00 Quite Low
Frailty 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Tendinopathy 1 5.00 Very Low Very Low Very Low
Pseudarthrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On one side, IL-10 has proanabolic effects, such as promotion of proteoglycan synthesis by human chondrocytes "in vitro" [17], prevention of cartilage destruction by reducing IL-1 and TNF-alpha mRNA expression in articular chondrocytes [17]; on the other side, IL-10 may also exert procatabolic effects as in human fibroblasts it down-regulates type I collagen mRNA expression and enhances collagenase and stromelysin gene expression [18].
IL-10 Positive_regulation (enhances) of Gene_expression (expression) of collagenase in cartilage
1) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.48 Pain Relevance 0.22

General Comments

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