INT227909

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10, TNF) extracellular region (IL10, TNF) intracellular (IL10, TNF)
signal transduction (TNF) plasma membrane (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 2
IL10 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 37 87.04 High High
metalloproteinase 9 74.84 Quite High
cytokine 2 61.32 Quite High
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Tendonitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 12 96.20 Very High Very High Very High
Knee Osteoarthritis 36 87.04 High High
Apoptosis 1 58.88 Quite High
Frailty 2 50.32 Quite High
Shock 5 50.00 Quite Low
Necrosis 2 50.00 Quite Low
Cancer 1 50.00 Quite Low
Injury 2 23.24 Low Low
Tendinopathy 1 5.00 Very Low Very Low Very Low
Pseudarthrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 activates a broad range of functional responses in different cell types inducing either inhibitory or stimulatory effects, such as down-regulating IL-1 and TNF-alpha synthesis by monocytes [8] or promoting the growth and differentiation of B cells [9].
IL-10 Regulation (regulating) of Gene_expression (synthesis) of TNF-alpha in monocytes
1) Confidence 0.21 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.57 Pain Relevance 0.38

General Comments

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