INT228333

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.53 Pain Relevance 0.09

cytosol (IRF9) nucleoplasm (IRF9) nucleus (IRF9) cytoplasm (IRF9)

Anatomy Link Frequency nucleus 1 IFNA1 (Homo sapiens) IRF9 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 2 68.04 fibrosis 5 54.56 Multiple sclerosis 20 45.60 anesthesia 1 10.48 Central nervous system 1 8.32 Inflammation 1 6.80 imagery 3 5.00 depression 2 5.00 Bioavailability 1 5.00 antidepressant 1 5.00

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 91 65.36 Hepatotoxicity 3 63.72 Disease 11 62.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 22 58.32 Fibrosis 2 54.56 Cirrhosis 6 51.40 Demyelinating Disease 22 50.00 Chronic Hepatitis 1 50.00 Injury 1 49.20 Infection 1 42.32

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Anatomy

Negation

Speculation

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Disease term

The activated STAT1/2 complex then migrates to the cell nucleus, forming a complex with IFN-regulatory factor 9 (IRF-9) where interaction with cellular DNA leads to expression of IFN-stimulated genes (ISGs).

IFN Binding (complex) of IRF-9 in nucleus

1) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.47 Pain Relevance 0.09

One pathway, leads to activation of the transcription factor IFN-stimulated gene factor 3 (ISGF3), a complex of phosphorylated Signal Transducer and Activator of Transcription (STAT) 2 with STAT1 and IFN regulatory factor 9 (IRF-9; p48) that binds to the IFN-stimulated response element (ISRE) present in multiple genes.[8], [9] The other pathway involves STAT2/1 and STAT2/3 heterodimers and STAT1 homodimer (IFN-?

IFN Binding (binds) of IRF-9

2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0.06 Pain Relevance 0

General Comments

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