INT228456

Context Info Confidence 0.24 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.12

cytosol (Trpv1) transport (Trpv1) extracellular space (Igf1) extracellular region (Igf1) plasma membrane (Trpv1) transmembrane transport (Trpv1)

Igf1 (Mus musculus) Trpv1 (Mus musculus)

Pain Link Frequency Relevance Heat Hyperalgesia 14 61.28 dorsal root ganglion 42 56.12 Pain 22 50.00 Spinal cord 6 35.24 Deafferentation 1 21.44 diabetic neuropathy 17 5.00 hypoalgesia 14 5.00 qutenza 10 5.00 Dopamine 3 5.00 Thermal hyperalgesia 3 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 118 98.36 Hyperglycemia 8 90.36 Hyperalgesia 48 78.88 Targeted Disruption 36 57.36 Ganglion Cysts 42 56.12 Pain 21 50.00 Neuropathic Pain 8 47.28 Stress 1 15.60 Peripheral Neuropathy 17 5.00 Hypoalagesia 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previously, we showed that insulin and IGF-1, acting via the IGF-1 receptor, potentiates TRPV1 current by activating PKC [50].

IGF-1 Positive_regulation (potentiates) of TRPV1

1) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.97 Pain Relevance 0.12

General Comments

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