INT228918

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 1.32

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn) extracellular matrix organization (Postn)

Postn (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 83 100.00 Morphine 75 99.84 Hyperalgesia 22 85.56 Opioid 52 78.76 Central nervous system 1 72.28 Oxycodone 1 65.40 Pain 18 60.92 Neuropathic pain 1 29.40 allodynia 11 11.48 withdrawal 6 5.00

Disease Link Frequency Relevance Heat Nociception 32 91.96 Sprains And Strains 2 87.08 Hyperalgesia 22 85.56 Pain 21 60.92 Burns 1 38.16 Psoriasis 2 37.36 Neuropathic Pain 12 29.40 Injury 14 6.40 Urological Neuroanatomy 9 5.00 INFLAMMATION 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More importantly, we went on in the present studies to show that the peri-incisional expression of cytokines previously demonstrated to be inhibited by morphine given acutely before incision [31] were moderately to strongly enhanced in the tissues of mice chronically pretreated with morphine.

Negative_regulation (inhibited) of Gene_expression (expression) of peri-incisional associated with morphine and cytokine

1) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2279109 Disease Relevance 0.44 Pain Relevance 1.32

General Comments

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