INT229200

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 21
Disease Relevance 8.96
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pc) ligase activity (Pc)
Anatomy Link Frequency
brains 3
Blood 2
spine 1
adult brain 1
body 1
Pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 712 99.80 Very High Very High Very High
ischemia 90 99.04 Very High Very High Very High
tolerance 9 74.72 Quite High
Inflammation 26 71.76 Quite High
alcohol 32 68.56 Quite High
Dismenorea 42 67.88 Quite High
Pain 16 66.88 Quite High
Potency 8 66.48 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
halothane 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 48 99.96 Very High Very High Very High
Endometriosis (extended) 724 99.80 Very High Very High Very High
Stroke 243 99.16 Very High Very High Very High
Cv General 4 Under Development 45 99.04 Very High Very High Very High
Brain Hemorrhage 72 95.58 Very High Very High Very High
Disease 168 93.88 High High
Injury 99 92.84 High High
Chronic Disease 8 91.84 High High
Middle Cerebral Artery Infarction 126 89.44 High High
Stress 18 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PCB production was banned in the United States in 1976, PCBs persist in the air, water, and soil and have accumulated in the fatty tissue of fish, birds, and mammals worldwide.
Gene_expression (production) of PCB
1) Confidence 0.65 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 1.04 Pain Relevance 0.47
If patterns of decreasing PCB body burden continue in the general U.S. population as they have since the PCB ban in 1976, our results suggest that environmental PCB exposure is likely too low to play a measurable role in the etiology of endometriosis.
Gene_expression (exposure) of PCB in body associated with endometriosis
2) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.39 Pain Relevance 0.19
Further evaluation in population-based studies conducted in occupational or environmental settings is needed to assess associations with higher PCB exposures.



Gene_expression (exposures) of PCB
3) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.30 Pain Relevance 0.15
Weight change, which may affect PCB levels, is not a typical symptom of endometriosis onset; therefore, we do not consider this type of exposure misclassification to be likely.
Gene_expression (levels) of PCB associated with endometriosis
4) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.89 Pain Relevance 0.20
If women had abnormally high PCB levels, the use of the control group could potentially mask any true association between PCB exposure and endometriosis.
Gene_expression (exposure) of PCB associated with endometriosis
5) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.75 Pain Relevance 0.28
We analyzed variables for each PCB congener (as quartile categories or the log-transformed continuous variable) or ?
Spec (analyzed) Gene_expression (congener) of PCB
6) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.09 Pain Relevance 0.11
The sum of the PCB congeners (?
Gene_expression (sum) of PCB
7) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.09 Pain Relevance 0.07
We made this choice because of the possibility that women with other gynecological conditions, many of which are estrogen related, may not be representative of the population at risk in terms of their PCB exposure.
Gene_expression (exposure) of PCB
8) Confidence 0.56 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944090 Disease Relevance 0.61 Pain Relevance 0.24
Blood lipid levels of PeCDF, PCB-126, and PCB-169 were log-transformed with a base of 10 because of their highly skewed distribution.
Gene_expression (levels) of PCB in Blood
9) Confidence 0.55 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0 Pain Relevance 0
Blood lipid levels of PeCDF, PCB-126, and PCB-169 were log-transformed with a base of 10 because of their highly skewed distribution.
Gene_expression (levels) of PCB in Blood
10) Confidence 0.48 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2367658 Disease Relevance 0 Pain Relevance 0
Animals and PCB exposures
Gene_expression (exposures) of PCB
11) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.65 Pain Relevance 0.15
Although our findings are paradoxical in that developmental PCB exposure was observed to protect against stroke damage, they are of public health significance in that they identify developmental exposures to environmental contaminants as potentially significant determinants of adult susceptibility to cerebral ischemia.
Gene_expression (exposure) of PCB associated with cv general 4 under development, stroke and ischemia
12) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.84 Pain Relevance 0.16
Of the 32 congeners chosen for analysis based on their toxicity, presence in A1254, abundance in environmental samples, and analytical capability, 31 were below the detection limit in brains of vehicle controls (Table 2); the one congener that was detected (PCB-153) was observed in only one of four samples, and the concentration in this sample was not significantly different from background.
Spec (observed) Gene_expression (presence) of PCB in brains associated with toxicity
13) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.23 Pain Relevance 0
One possible mechanism is differences in PCB metabolism between the sexes.
Gene_expression (metabolism) of PCB
14) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.30 Pain Relevance 0
Determining which type(s) of PCBs contribute to the observed effects will improve assessments of PCB risks to human health, and identifying cellular and molecular mechanisms of PCB-induced neuroprotection will be necessary for translating these novel findings into potential stroke therapies.



Gene_expression (neuroprotection) of PCB-induced associated with stroke
15) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.42 Pain Relevance 0
Effects of developmental A1254 exposure on hepatic CYP activity and adult brain PCB levels
Gene_expression (levels) of PCB in adult brain
16) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.41 Pain Relevance 0
Animals and PCB exposures
Gene_expression (Animals) of PCB
17) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.65 Pain Relevance 0.15
Analyses of PCB levels in human brains obtained from the general adult population similarly identified predominantly ortho-substituted congeners at concentrations ranging from 0.07 to 8.0 ng/g wet weight (Chu et al. 2003; Covaci et al. 2002; Dewailly et al. 1999).
Gene_expression (levels) of PCB in brains
18) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.51 Pain Relevance 0.06
Thus, the protective effects of PCBs in ischemic brain injury appear to be independent of PCB effects on the vasculature and homeostatic regulation of blood glucose, suggesting that although PCB exposure may increase risk factors for stroke incidence, such effects may be offset by PCB-induced neuroprotection that decreases the extent of damage caused by ischemic stroke.
Gene_expression (neuroprotection) of PCB-induced in brain associated with brain hemorrhage and stroke
19) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.78 Pain Relevance 0.08
There was no significant change in cortical volumetric BMD in either the PTH followed by ALN or PTH followed by Pcb groups.
Gene_expression (groups) of Pcb
20) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0 Pain Relevance 0

General Comments

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