INT229235

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.70
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
HeLa 3
SiHa 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 94.72 High High
ischemia 22 79.12 Quite High
Inflammation 54 73.28 Quite High
COX-2 inhibitor 104 43.60 Quite Low
bradykinin 3 40.60 Quite Low
Opioid 2 40.00 Quite Low
cINOD 34 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 358 100.00 Very High Very High Very High
Cervical Cancer 4 97.44 Very High Very High Very High
INFLAMMATION 59 94.16 High High
Skin Cancer 10 89.52 High High
Death 66 84.40 Quite High
Cv Unclassified Under Development 21 79.12 Quite High
Toxicity 4 55.96 Quite High
Cancer 254 54.28 Quite High
Necrosis 14 50.00 Quite Low
Colon Cancer 46 20.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preconditioning causes a decrease in pro-apoptotic Bax and increase in the anti-apoptotic Bcl-2 proteins resulting in an altered Bcl-2/Bax ratio and attenuation of cytochrome c release from mitochondria (Maulik et al 1999, 2000; Nakamura et al 2000).
Regulation (altered) of Localization (release) of Bcl-2 associated with apoptosis
1) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.23 Pain Relevance 0.15
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Regulation (regulation) of Localization (release) of Bcl-2 in HeLa associated with apoptosis
2) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Regulation (regulation) of in SiHa Localization (release) of Bcl-2 in HeLa associated with apoptosis
3) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0

General Comments

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