INT229302

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 3.36
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FXR1) nucleolus (FXR1) RNA binding (FXR1)
nucleus (FXR1) cytoplasm (FXR1)
Anatomy Link Frequency
bile 1
FXR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 351 99.18 Very High Very High Very High
Cholecystokinin 9 87.36 High High
agonist 18 74.56 Quite High
nud 18 5.00 Very Low Very Low Very Low
Migraine 9 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Inflammatory marker 9 5.00 Very Low Very Low Very Low
Sumatriptan 9 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 54 99.52 Very High Very High Very High
Diabetes Mellitus 261 98.56 Very High Very High Very High
Disorder Of Lipid Metabolism 207 86.20 High High
Metabolic Disorder 9 84.36 Quite High
Obesity 27 79.28 Quite High
Body Weight 9 77.84 Quite High
Insulin Resistance 9 64.88 Quite High
Impaired Glucose Tolerance 9 63.04 Quite High
Hyperglycemia 27 58.52 Quite High
Coronary Artery Disease 225 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further more, activation of FXR has been shown to lower glucose levels in mice with diabetes mellitus (Zhang et al 2006).
Positive_regulation (activation) of FXR associated with diabetes mellitus
1) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.31 Pain Relevance 0.20
As noted before, activation of FXR lowers glucose levels in mice with diabetes mellitus (Zhang et al 2006).
Positive_regulation (activation) of FXR associated with diabetes mellitus
2) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.48 Pain Relevance 0.03
FXR activation normally induces expression of small heterodimer partner (SHP), which in turn, inhibits LXR activity, as well as CYP7A1 (Brendel et al 2002).
Positive_regulation (activation) of FXR
3) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.57 Pain Relevance 0.04
But FXR activation not only has direct effects, but also has important indirect effects that may affect glucose metabolism.
Positive_regulation (activation) of FXR
4) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.38 Pain Relevance 0.04
This glucose lowering may be the net result of the direct and indirect effects of FXR activation.
Positive_regulation (activation) of FXR
5) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.45 Pain Relevance 0.03
One of the important indirect effects of FXR activation relates to LXR.
Positive_regulation (activation) of FXR
6) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.51 Pain Relevance 0.03
Studies have shown that the activation of this enzyme may be only partially mediated by FXR (Kerr et al 2002) while other studies have suggested that the activation of CYP7A1 is independent of either LXR or FXR activity (Shibata et al 2007).
Positive_regulation (activation) of FXR
7) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.34 Pain Relevance 0.07
Another study suggests that FXR activation actually impairs hepatic gluconeogenic genes such as PEPCK (Ma et al 2006), and increases hepatic glycogen synthesis, all potentially mediated through enhanced insulin sensitivity.
Positive_regulation (activation) of FXR
8) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.22 Pain Relevance 0.25
Bile acids are a natural ligand for FXR, and activation of FXR results in repression of CYP7A1, thereby reducing bile acid synthesis.
Positive_regulation (activation) of FXR in bile associated with bile and repression
9) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.10 Pain Relevance 0.46

General Comments

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