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Context Info
Confidence 0.25
First Reported 1983
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.26
Pain Relevance 0.98

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mRNA binding (MBD2) nucleus (MBD2) DNA binding (MBD2)
cytoplasm (MBD2)
Anatomy Link Frequency
livers 1
MBD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
methadone 2 99.68 Very High Very High Very High
anesthesia 2 90.68 High High
qutenza 1 87.52 High High
Physical dependence 1 70.48 Quite High
analgesia 1 58.12 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 100.00 Very High Very High Very High
Weight Gain 2 86.40 High High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytochromes P-450 and b5, NADPH and NADH cytochrome c reductase, methadone and meperidine N-demethylase and morphine glucuronyltransferase activities were detected in microsomes from both maternal and fetal livers.
Gene_expression (detected) of N-demethylase in livers associated with methadone and morphine
1) Confidence 0.25 Published 1986 Journal Dev Pharmacol Ther Section Abstract Doc Link 3757733 Disease Relevance 0 Pain Relevance 0.39
The correlation between PPX formation and erythromycin N-demethylase activity showed an R value of 0.99 whereas anti-rabbit CYP3A6 antibody inhibited the degradation of bupivacaine into PPX by 99%.
Gene_expression (formation) of N-demethylase
2) Confidence 0.15 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10725304 Disease Relevance 0 Pain Relevance 0.12
Separation of hepatic N-demethylase-inducing and opioid dependence-producing doses of levo-alpha-acetylmethadol in the pregnant rat.
Gene_expression (producing) of N-demethylase associated with addiction and opioid
3) Confidence 0.11 Published 1983 Journal Life Sci. Section Title Doc Link 6684201 Disease Relevance 0.26 Pain Relevance 0.30
At specified p.o. periods, hepatic microsomal total protein, cytochrome P-450 and activities of the enzymes, aminopyrine demethylase and benzo[a]pyrene hydroxylase were determined for the respective pairs and submitted to analysis of variance.
Spec (determined) Gene_expression (determined) of demethylase
4) Confidence 0.02 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353131 Disease Relevance 0 Pain Relevance 0.09
Cumin, ginger and fenugreek also stimulated the levels of cytochrome P450 and cytochrome b5 and cumin and tamarind stimulated N-demethylase activity.
Gene_expression (levels) of N-demethylase
5) Confidence 0.01 Published 1989 Journal Indian J. Biochem. Biophys. Section Abstract Doc Link 2628260 Disease Relevance 0 Pain Relevance 0.09

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