INT229500

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.79 Pain Relevance 0.07

cytoplasm (Vim, Nde1) cytoskeleton (Vim, Nde1) cell differentiation (Nde1) microtubule organizing center (Nde1) cytosol (Vim) mitosis (Nde1)

Anatomy Link Frequency neurite 3 Vim (Mus musculus) Nde1 (Mus musculus)

Pain Link Frequency Relevance Heat Sciatic nerve 93 71.68 Spinal cord 30 29.76 dorsal root ganglion 57 5.52 butorphanol 3 5.00 Analgesic 3 5.00 Dorsal column 3 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Coronary Artery Disease 9 97.56 Schizophrenia 3 97.48 Neuroblastoma 3 90.32 Targeted Disruption 9 89.44 Injury 63 62.96 Embryonic Lethality 6 44.92 Ganglion Cysts 66 33.20 Neurodegenerative Disease 3 32.04 Nervous System Injury 6 5.00 Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The important role of Nde1l in neurite outgrowth and its association with Vimentin, an IF with dual role in axon regeneration, raised the question whether Ndel1 promotes or impedes axon regeneration in vivo.

Vimentin Binding (association) of Nde1l in neurite

1) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0

Recently, we found that Nde1l forms a molecular complex with the IF Vimentin and regulates Vimentin dynamics during neurite extension in CAD cells [23].

Vimentin Binding (complex) of Nde1l in neurite associated with coronary artery disease

2) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.35 Pain Relevance 0.04

Recently, we found that Nde1l forms a molecular complex with the IF Vimentin and regulates Vimentin dynamics during neurite extension in CAD cells [23].

Vimentin Binding (forms) of Nde1l in neurite associated with coronary artery disease

3) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

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