INT229518

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.62
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
Brain 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 30 88.08 High High
adenocard 2 62.32 Quite High
depression 6 52.76 Quite High
nMDA receptor 13 38.32 Quite Low
isoflurane 1 18.56 Low Low
anesthesia 3 17.60 Low Low
Glutamate 2 16.08 Low Low
Hippocampus 15 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 29 99.18 Very High Very High Very High
Death 16 99.16 Very High Very High Very High
Disease 125 95.52 Very High Very High Very High
Drug Induced Neurotoxicity 2 95.12 Very High Very High Very High
Targeted Disruption 37 94.64 High High
Neuroblastoma 5 84.92 Quite High
Sprains And Strains 52 80.76 Quite High
Scrapie 26 65.68 Quite High
Depression 6 52.76 Quite High
Toxicity 6 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of GA on the steady-state level of PrPC
Phosphorylation (level) of PrPC
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.26 Pain Relevance 0
Treatment of cells with FK506 in the absence of PrPSc did not change cell death or viability (data not shown).
Neg (absence) Phosphorylation (absence) of PrPSc associated with death
2) Confidence 0.60 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.59 Pain Relevance 0
Brain homogenates of mice inoculated with the amyloid preparations exhibited the PK-resistant form of PrPSc.
Phosphorylation (form) of PrPSc in Brain associated with alzheimer's dementia
3) Confidence 0.55 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.53 Pain Relevance 0
Deglycosylation of PrPSc
Phosphorylation (Deglycosylation) of PrPSc
4) Confidence 0.47 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 0 Pain Relevance 0
oligomers, and the infectious prion protein PrP(Sc) conformation is not required for the interaction.48,49 The binding of A?
Phosphorylation (conformation) of PrP
5) Confidence 0.11 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 0.24 Pain Relevance 0.27

General Comments

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