INT2296

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 137
Total Number 139
Disease Relevance 36.96
Pain Relevance 35.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 40
plasma 28
lactotrophs 15
brain 6
platelets 6
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 38 100.00 Very High Very High Very High
medulla 21 100.00 Very High Very High Very High
narcan 92 99.98 Very High Very High Very High
Morphine 109 99.84 Very High Very High Very High
Analgesic 11 99.82 Very High Very High Very High
Dynorphin 20 99.76 Very High Very High Very High
Dopamine 402 99.68 Very High Very High Very High
fluoxetine 25 99.62 Very High Very High Very High
Clonidine 26 99.54 Very High Very High Very High
antagonist 742 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 2 91 100.00 Very High Very High Very High
Diabetes Insipidus 3 99.96 Very High Very High Very High
Stress 1092 99.92 Very High Very High Very High
Cancer 668 99.90 Very High Very High Very High
Diuresis 1 99.88 Very High Very High Very High
Depression 59 99.84 Very High Very High Very High
Reprotox - General 1 37 99.84 Very High Very High Very High
Decapitation 12 99.84 Very High Very High Very High
Galactorrhea 116 99.68 Very High Very High Very High
Anxiety Disorder 216 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single injection of morphine also resulted 4 hr later in an attenuation of the PRL response to a second injection of morphine (7.5 mg/kg); however, the increase in serum PRL concentration produced by alpha-methyltyrosine (250 mg/kg) was unaltered by prior morphine administration.
Positive_regulation (increase) of Gene_expression (produced) of PRL associated with morphine
1) Confidence 0.70 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.17 Pain Relevance 1.35
However, morphine+naloxone administration increased mean serum prolactin levels and the absolute amplitudes of prolactin pulses in pituitary-grafted rats.
Positive_regulation (increased) of Gene_expression (levels) of prolactin in pituitary associated with narcan and morphine
2) Confidence 0.70 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.74
Training the animals to be handled prevented the increase in plasma prolactin levels produced by decapitation; training had no influence on the decapitation-induced rises in plasma CA concentrations.
Positive_regulation (increase) of Gene_expression (produced) of prolactin in plasma associated with catecholamine and decapitation
3) Confidence 0.70 Published 1981 Journal J Pharmacol Methods Section Abstract Doc Link 7311568 Disease Relevance 0.20 Pain Relevance 0.36
These experiments demonstrated a dramatic (40-fold) upregulation of prolactin (PRL) expression in TG by 17-beta-estradiol (E2).
Positive_regulation (upregulation) of Gene_expression (expression) of prolactin
4) Confidence 0.70 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16885226 Disease Relevance 0.18 Pain Relevance 0.17
There is an age-related increase in the cell population engaged in prolactin secretion, as well as an increase in the synthesis of prolactin and of the amount of prolactin secreted from individual lactotropes. 3.
Positive_regulation (increase) of Gene_expression (synthesis) of prolactin in lactotropes
5) Confidence 0.70 Published 1992 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 1571952 Disease Relevance 0.07 Pain Relevance 0.12
Mifepristone increased prolactin mRNA and protein expression.
Positive_regulation (increased) of Gene_expression (expression) of prolactin
6) Confidence 0.69 Published 2009 Journal Neuroendocrinology Section Body Doc Link 18832805 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: (1) Blockade of progesterone action by mifepristone activated the lactotrope, increased significantly prolactin mRNA and protein expression and prepared the pituitary for naloxone action. (2) The high serum prolactin levels induced by mifepristone and naloxone may regulate negatively lactotrope activity as suggested by the presence of regressing cells neighboring the actively secreting cells.


Positive_regulation (increased) of Gene_expression (expression) of prolactin in lactotrope
7) Confidence 0.69 Published 2009 Journal Neuroendocrinology Section Body Doc Link 18832805 Disease Relevance 0 Pain Relevance 0
M increased serum PRL levels in immature rats of both sexes in all age groups, except in 25-day-old males, whereas N decreased serum PRL only in 25-day-old male rats.
Positive_regulation (increased) of Gene_expression (levels) of PRL
8) Confidence 0.69 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 514456 Disease Relevance 0 Pain Relevance 0.31
Intraperitoneal administration of phencyclidine (PCP, 2.5-20 mg/kg) produced a dose-related inhibition of the increase in serum PRL concentrations produced by alpha-methylparatyrosine (AMPT) or reserpine, but not morphine.
Positive_regulation (increase) of Gene_expression (produced) of PRL associated with morphine
9) Confidence 0.69 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 4007050 Disease Relevance 0 Pain Relevance 0.27
Furthermore, estradiol can also stimulate prolactin synthesis and release by directly targeting the lactotrophes [33].
Positive_regulation (stimulate) of Gene_expression (synthesis) of prolactin
10) Confidence 0.68 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.36 Pain Relevance 0.10
To answer this question, we injected post-partum animals with estradiol benzoate plus bromoergocryptine in order to block the production of pituitary prolactin induced by the estrogen.
Positive_regulation (induced) of Gene_expression (production) of prolactin in pituitary
11) Confidence 0.68 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.11 Pain Relevance 0
The results revealed that the MR-2266-BS of 3 mg/kg completely blocked the restraint stress-induced increase in plasma ACTH levels, and further elevated plasma PRL levels in these animals, while there were no effects on the resting levels of ACTH and PRL.
Positive_regulation (elevated) of Gene_expression (levels) of PRL in plasma associated with stress
12) Confidence 0.68 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2557673 Disease Relevance 0.25 Pain Relevance 0.38
Hyperprolactinemia is characterized by increased production of prolactin, often leading to reproductive dysfunction and galactorrhea.
Positive_regulation (increased) of Gene_expression (production) of prolactin associated with galactorrhea
13) Confidence 0.67 Published 1999 Journal Int J Fertil Womens Med Section Abstract Doc Link 10338264 Disease Relevance 0.98 Pain Relevance 0
The control of prolactin release is further complicated by the fact that oestradiol stimulates prolactin synthesis and release by a direct action on the prolactotrophes.
Positive_regulation (stimulates) of Gene_expression (synthesis) of prolactin
14) Confidence 0.67 Published 1988 Journal J. Steroid Biochem. Section Abstract Doc Link 3290579 Disease Relevance 0 Pain Relevance 0.07
However, the increase in serum prolactin levels produced by 5-HTP plus 5-HT reuptake blockade in lesioned rats was not significantly different from sham-operated rats if as little as 15-20% of control median eminence accumulation was present.
Positive_regulation (increase) of Gene_expression (produced) of serum prolactin in median eminence
15) Confidence 0.61 Published 1984 Journal Brain Res. Section Abstract Doc Link 6610456 Disease Relevance 0 Pain Relevance 0.26
Bromocriptine therapy suppressed serum PRL levels of five patients without tumors but increased the PRL-releasing activity in three out of five patients after treatment for 1 or 2 months.
Positive_regulation (increased) of Gene_expression (releasing) of PRL-releasing associated with cancer
16) Confidence 0.50 Published 1983 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6405619 Disease Relevance 0.77 Pain Relevance 0.15
Intracerebroventricular injection of norepinephrine (2 micrograms/rat) or epinephrine (100 ng and 1 microgram/rat) caused an increase in plasma PRL levels.
Positive_regulation (increase) of Gene_expression (levels) of PRL in plasma associated with intracerebroventricular
17) Confidence 0.50 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2813439 Disease Relevance 0 Pain Relevance 0.49
We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.
Positive_regulation (increased) of Gene_expression (content) of PRL in pituitary associated with fluoxetine
18) Confidence 0.50 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.22
Serum PRL levels before, during, and after major gynecologic surgery were measured in 20 women randomly assigned to one of four pretreatment regimens: (1) dexamethasone, (2) promethazine, (3) both agents, and (4) neither agent.
Positive_regulation (measured) of Gene_expression (levels) of PRL associated with dexamethasone
19) Confidence 0.50 Published 1978 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 707580 Disease Relevance 0.09 Pain Relevance 0.19
The drawing of blood by orbital sinus puncture (OSP) under ether anesthesia is known to produce a marked increase in serum prolactin (PRL levels in young cycling female rats.
Positive_regulation (increase) of Gene_expression (levels) of prolactin in sinus associated with anesthesia
20) Confidence 0.50 Published 1983 Journal Life Sci. Section Abstract Doc Link 6682168 Disease Relevance 0.16 Pain Relevance 0.10

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