INT229626

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.00
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
coronary artery 4
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 56 99.60 Very High Very High Very High
psoriasis 1 73.72 Quite High
imagery 31 67.88 Quite High
Inflammation 15 63.16 Quite High
withdrawal 1 53.12 Quite High
bradykinin 41 45.92 Quite Low
b2 receptor 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 6 99.80 Very High Very High Very High
Coronary Heart Disease 1 99.74 Very High Very High Very High
Coronary Artery Disease 10 98.96 Very High Very High Very High
Nicotine Addiction 2 97.52 Very High Very High Very High
Cancer 14 96.10 Very High Very High Very High
Diabetes Mellitus 70 94.18 High High
Diabetic Retinopathy 3 78.36 Quite High
Psoriasis 1 73.72 Quite High
Ocular Toxicity (including Many Sub-types) 3 69.44 Quite High
INFLAMMATION 21 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T1D and H donors with conditions reported to affect function of angiogenic cells (pregnancy, tumors, peripheral or coronary artery disease, hypertension, habitual smoking, extensive exercise training (e.g. marathon runners), over 55 years of age or taking medication affecting kinin signaling (ACE inhibitors, angiotensin receptor blockers) were excluded from both study groups.
Negative_regulation (inhibitors) of Localization (blockers) of ACE in coronary artery associated with nicotine addiction, coronary artery disease, cancer, diabetes mellitus and hypertension
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 1.41 Pain Relevance 0.09
These patients were newly diagnosed with coronary artery disease, some of whom were taking vasoactive drugs such as ACE inhibitors and beta adrenoceptor blockers for hypertension prior to study enrolment.
Negative_regulation (inhibitors) of Localization (blockers) of ACE in coronary artery associated with coronary artery disease and hypertension
2) Confidence 0.29 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.25 Pain Relevance 0.09
Earlier scientific investigations proved that ACE and MMPs are closely related to coronary diseases and the ACE inhibitors not only target ACE but also MMPs.
Negative_regulation (inhibitors) of Localization (target) of ACE associated with metalloproteinase and coronary heart disease
3) Confidence 0.07 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.34 Pain Relevance 0.18

General Comments

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