INT229789

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 7.09
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RAB7A) GTPase activity (RAB7A) lysosome (RAB7A)
Anatomy Link Frequency
thyroid 1
neurons 1
HeLa 1
vesicles 1
RAB7A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 94 83.04 Quite High
Pain 39 82.56 Quite High
imagery 59 79.44 Quite High
Nerve growth factor 11 68.72 Quite High
Congenital analgesia 11 65.36 Quite High
Demyelination 12 25.44 Quite Low
Neurotransmitter 1 11.52 Low Low
Peripheral nervous system 11 10.68 Low Low
lancinating pain 2 5.00 Very Low Very Low Very Low
unmyelinated 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 874 99.78 Very High Very High Very High
Neurodegenerative Disease 44 99.52 Very High Very High Very High
Adenoma 1 98.20 Very High Very High Very High
Diabetes Mellitus 4 96.40 Very High Very High Very High
Infection 90 95.92 Very High Very High Very High
Syndrome 50 93.60 High High
Diabetes Insipidus 1 93.04 High High
Repression 2 87.56 High High
Neuropathic Pain 25 84.72 Quite High
Hereditary Sensory And Autonomic Neuropathies 106 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These properties render Rabs, including Rab7, dependent on the positive and negative influences of regulatory GEF and GAP proteins.
Regulation (dependent) of Rab7
1) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.46 Pain Relevance 0
How might misregulation of Rab7 lead to axonal degeneration?
Regulation (misregulation) of Rab7
2) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.37 Pain Relevance 0
Our data suggest that misregulation of the Rab7 activity cycle in disease mutants may perturb such carefully orchestrated vesicular trafficking pathways.
Regulation (misregulation) of Rab7 associated with disease
3) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.62 Pain Relevance 0
These results suggest that the misregulation of the Rab7 activity cycle in disease mutants leads to the augmentation of specific effector interactions.
Regulation (misregulation) of Rab7 associated with disease
4) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.58 Pain Relevance 0
Misregulation of Rab7 function as seen in CMT2B may have the opposite effect, resulting in premature lysosomal degradation of endocytic vesicles.
Regulation (Misregulation) of Rab7 in vesicles
5) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.40 Pain Relevance 0.26
We report that misregulation of Rab7 activation results in an increase in the active fraction of Rab7 and abnormal retention on target membranes.
Regulation (misregulation) of Rab7
6) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.58 Pain Relevance 0
Thus, we demonstrate that disease mutations uncouple Rab7 from the spatial and temporal control normally imposed by regulatory proteins and cause disease not by a gain of novel toxic function, but by misregulation of native Rab7 activity.



Neg (not) Regulation (misregulation) of Rab7 associated with disease
7) Confidence 0.42 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2830827 Disease Relevance 0.53 Pain Relevance 0.04
The RAB7 gene has been localised to late endosomes and has been shown to be important in the late endocytic pathway.
Regulation (important) of RAB7
8) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.64 Pain Relevance 0.42
Members of the Rab family of small GTPases such as Rab7 are master regulators of vesicular trafficking, maturation and fusion.
Regulation (regulators) of Rab7
9) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.09 Pain Relevance 0
To determine whether disease mutations affect Rab7 subcellular localization, we analyzed the distribution of GFP-tagged Rab7 in HeLa cells.
Spec (whether) Regulation (affect) of Rab7 in HeLa associated with disease
10) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.54 Pain Relevance 0
Our findings of subtle changes in Rab7 activity are consistent with this pattern of disease in which a slight underlying defect becomes pathological only in a subset of vulnerable neurons.
Regulation (changes) of Rab7 in neurons associated with disease
11) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.56 Pain Relevance 0
Thus, our data reveal how misregulation of multiple steps of the Rab7 activity cycle leads to the alteration of Rab7 activity.
Regulation (alteration) of Rab7
12) Confidence 0.25 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.54 Pain Relevance 0
Our primary siRNA screen has also indicated that targeting of the endocytic trafficking proteins and associated kinases, Rab5A, Rab7, Rab11b, ELKS, early endosome antigen 1 and MAPK8IP2, each resulted in significant decreases in DENV infection (Figure 2 and Additional File 2).
Regulation (targeting) of Rab7 associated with infection
13) Confidence 0.24 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.51 Pain Relevance 0
The control of thyroid hormone production depends on endocytic catalysts and the tandem regulators Rab5a and Rab7, which have been found in excess in thyroid adenomas [8].


Regulation (regulators) of Rab7 in thyroid associated with adenoma
14) Confidence 0.18 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.67 Pain Relevance 0

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