INT22984

Context Info Confidence 0.67 First Reported 1990 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 5.24 Pain Relevance 2.25

Anatomy Link Frequency neurons 3 skin 1 thoracic 1 FRTS (Homo sapiens)

Pain Link Frequency Relevance Heat inferior alveolar nerve 302 99.24 antagonist 1 99.06 anesthesia 9 96.88 Somatosensory cortex 16 96.58 Thoracotomy 46 96.36 halothane 5 92.28 Spinal cord 3 91.76 GABAergic 14 91.36 Dorsal horn neuron 3 89.80 lidocaine 6 87.52

Disease Link Frequency Relevance Heat Recurrence 53 100.00 Cardiovascular Disease 67 99.98 Acquired Immune Deficiency Syndrome Or Hiv Infection 32 99.84 Adenocarcinoma 20 99.66 Metastasis 36 97.88 Gastric Regurgitation 11 97.76 Aging 73 96.60 Metabolic Syndrome 3 93.52 Cv Unclassified Under Development 65 92.60 Polyps 4 90.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Among 48 390 patients (82.3%) with a GI RF score of > or = 1, 20.9% used a GP strategy, this increased with number of GI RFs.

Positive_regulation (increased) of RFs

1) Confidence 0.67 Published 2009 Journal Curr Med Res Opin Section Body Doc Link 19210152 Disease Relevance 0 Pain Relevance 0

At a cortical level, we have demonstrated that the functional organization of the hindpaw representation in somatosensory cortex of aged rats undergoes a significant deterioration: Receptive fields (RFs) of neurons recorded in the hindpaw representations of aged rats were enlarged, overlap between RFs was increased, and the topographic organization of cortical representational maps was broken down [10].

Positive_regulation (increased) of RFs in neurons associated with somatosensory cortex

2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561003 Disease Relevance 0.27 Pain Relevance 0.18

While for the cortical region representing the skin areas of the forepaws only small, yet significant enlargements of RFs were observed in aged animals, RFs recorded in the hindpaw representation enlarged almost threefold.

Positive_regulation (enlargements) of RFs in skin

3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561003 Disease Relevance 0.07 Pain Relevance 0

The neurons were classified according to their responses to both innocuous and noxious mechanical stimulation of their RFs.

Positive_regulation (stimulation) of RFs in neurons

4) Confidence 0.11 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2358860 Disease Relevance 0.07 Pain Relevance 0.25

Like disruptions of peripheral inputs, disruptions of DCN inhibition by DCN administration of the GABAA receptor antagonist bicuculline methiodide (BMI) also cause rapid enlargements of DCN RFs when cortical inputs are intact.

Positive_regulation (enlargements) of RFs associated with antagonist

5) Confidence 0.06 Published 2006 Journal Brain Res. Section Abstract Doc Link 16697977 Disease Relevance 0 Pain Relevance 0.60

Comparison of the postoperative RFS and RSI scores between the two groups of patients with LPR showed statistically significant differences in both, indicating better treatment outcome in those patients who had received PPI.

Positive_regulation (postoperative) of RFS associated with gastric regurgitation

6) Confidence 0.05 Published 2009 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 18604546 Disease Relevance 1.13 Pain Relevance 0.08

If this is the case, one would expect to find a strong correlation between age-related enlargement of RFs and a reduction of PPS.

Positive_regulation (enlargement) of RFs

7) Confidence 0.04 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2852507 Disease Relevance 0.07 Pain Relevance 0.13

In total, 51% of neurons showed some kind of CF shift (type 1 or type 4 changes), 9% of neurons showed increases in firing rate within their RFs (type 2 changes), 11% of neurons showed unmasking of new activity (type 3), and 18% of these neurons showed CF changes resulting directly from unmasking (type 4 changes).

Positive_regulation (increases) of RFs in neurons

8) Confidence 0.04 Published 2008 Journal J Assoc Res Otolaryngol Section Body Doc Link PMC2644396 Disease Relevance 0 Pain Relevance 0

In cases of primary adenocarcinoma, VATS showed no increase in number of thoracic recurrences, and comparable RFS.

Neg (no) Positive_regulation (increase) of RFS in thoracic associated with adenocarcinoma and recurrence

9) Confidence 0.04 Published 2008 Journal Surg Endosc Section Abstract Doc Link PMC2730451 Disease Relevance 0.79 Pain Relevance 0.20

The mechanical stimulation of the RFs was considered to have induced an effect when the mean firing frequency at 5 s after mechanical stimulation differed from mean background discharge rate by ± 2SD.

Positive_regulation (stimulation) of RFs

10) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.37 Pain Relevance 0.21

This setup allowed convenient access to fibers which responded to stimulation of the orofacial RFs innervated by the IAN.

Positive_regulation (stimulation) of RFs associated with inferior alveolar nerve

11) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.12 Pain Relevance 0.58

Traditional CVD RFs are increased in HIV populations (14,15) and seem to predict risk in a similar fashion to uninfected populations (16).

Positive_regulation (increased) of RFs associated with cardiovascular disease and acquired immune deficiency syndrome or hiv infection

12) Confidence 0.02 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2913108 Disease Relevance 2.27 Pain Relevance 0.03

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