INT230264

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cav3) Golgi apparatus (Cav3) plasma membrane organization (Cav3)
plasma membrane (Cav3) enzyme binding (Cav3) protein complex (Cav3)
Anatomy Link Frequency
chondrocytes 1
spike 1
Cav3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 27 40.40 Quite Low
hyperexcitability 12 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
repetitive firing 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Nav1.1 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 51 5.00 Very Low Very Low Very Low
Convulsion 9 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normal rat chondrocytes, we observed relatively high levels of Cav-3 and a very low level of COX-2 mRNA and protein.
Positive_regulation (levels) of Cav-3 in chondrocytes
1) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
In Figure 6A, the effect of increasing gCaT for CaV3.1 is shown.
Positive_regulation (increasing) of CaV3
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0 Pain Relevance 0
In contrast, increasing CaV3.3 gCaT from 0.0 to 0.5 mS/cm2 causes an increase in the amplitude of the afterdepolarizing potential (ADP), but does not do so sufficiently to generate an additional spike (Figures 6Ca–b).
Positive_regulation (increasing) of CaV3 in spike
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0 Pain Relevance 0
In contrast, CaV3.3, with its slow activation and inactivation kinetics, is facilitated and contributes increasingly as the burst progresses.
Positive_regulation (facilitated) of CaV3
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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