INT230328

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RAD51) mitochondrion (RAD51) nucleus (RAD51)
cytoplasm (RAD51)
RAD51 (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 33.76 Quite Low
Shock 3 27.12 Quite Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Amebiasis 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Malaria 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some genes (Ehnbs1, Ehrad54 and Ehrad52/22) were down-regulated after DNA damage, others (Ehmre11, Ehrad51, Ehrad51-C and Ehrad52) were up-regulated at different times following genotoxic stimulus, whereas Ehrad50 mRNA levels were regulated in a variable manner, suggesting a complex transcriptional response.
Negative_regulation (regulated) of Ehrad51
1) Confidence 0.36 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Interestingly, the Ehrad51 transcript steady state levels were about 15-fold higher at 30 min post-UV-C treatment and decreased 3 and 12 h later, suggesting that EhRAD51 could be participating in HR in the early steps of DNA repair.
Negative_regulation (decreased) of Ehrad51
2) Confidence 0.36 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Some genes (Ehnbs1, Ehrad54 and Ehrad52/22) were down-regulated after DNA damage, others (Ehmre11, Ehrad51, Ehrad51-C and Ehrad52) were up-regulated at different times following genotoxic stimulus, whereas Ehrad50 mRNA levels were regulated in a variable manner, suggesting a complex transcriptional response.
Negative_regulation (regulated) of Ehrad51
3) Confidence 0.16 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
This suggests that HR is initiated normally in ERCC1-defective cells, the ERCC1–XPF being likely to have a role in HR in a step subsequent to the activities of the HR proteins RAD51D, XRCC3 or BRCA2, as those mutant cells are deficient in RAD51 foci formation (46,47).
Negative_regulation (deficient) of RAD51
4) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0

General Comments

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