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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 4.20
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Erlec1)
Anatomy Link Frequency
neurons 2
brain 2
M cells 2
poly 1
endothelial cells 1
Erlec1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 99.18 Very High Very High Very High
unmyelinated 7 98.42 Very High Very High Very High
Dorsal horn 3 98.28 Very High Very High Very High
Central nervous system 51 95.40 Very High Very High Very High
anesthesia 3 94.48 High High
Glutamate 2 87.08 High High
ischemia 20 83.04 Quite High
Glutamate receptor 1 81.76 Quite High
nociceptor 26 80.32 Quite High
Nerve growth factor 29 76.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 104 99.78 Very High Very High Very High
Pain 5 99.18 Very High Very High Very High
Nociception 4 98.66 Very High Very High Very High
Infection 172 95.80 Very High Very High Very High
Targeted Disruption 20 89.36 High High
Cv Unclassified Under Development 16 83.04 Quite High
Injury 37 79.72 Quite High
Neurocysticercosis 90 78.92 Quite High
Cv General 3 Under Development 1 76.40 Quite High
Hypertension 1 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under experimental conditions of glutamatergic hypofunction PN formation was studied in organotypic brain slice cultures with Wisteria floribunda lectin binding and with aggrecan immunohistochemistry.
lectin Binding (binding) of in brain
1) Confidence 0.40 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561838 Disease Relevance 0.35 Pain Relevance 0.25
After 7 days of culture, endothelial cells differentiated from EPCs were identified as adherent cells with 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine-labeled acetylated low density lipoprotein (Dil-Ac-LDL) uptake and lectin binding under a fluorescent microscope.
lectin Binding (binding) of in endothelial cells
2) Confidence 0.19 Published 2006 Journal Hypertens. Res. Section Abstract Doc Link 17378377 Disease Relevance 0.15 Pain Relevance 0.08
The similarities of lectin binding patterns in each of these species suggest that the glycoconjugate to which BSI-B(4) binds has a ubiquitous distribution in mammals, and supports the proposal that this lectin may preferentially bind to a subpopulation of sensory neurones with a similar functional role in each of these species.
lectin Binding (bind) of
3) Confidence 0.17 Published 2002 Journal Anat. Rec. Section Abstract Doc Link 12221716 Disease Relevance 0 Pain Relevance 0.05
The similarities of lectin binding patterns in each of these species suggest that the glycoconjugate to which BSI-B(4) binds has a ubiquitous distribution in mammals, and supports the proposal that this lectin may preferentially bind to a subpopulation of sensory neurones with a similar functional role in each of these species.
lectin Binding (binding) of
4) Confidence 0.13 Published 2002 Journal Anat. Rec. Section Abstract Doc Link 12221716 Disease Relevance 0 Pain Relevance 0.05
The purpose of the present study was to investigate the binding patterns of the plant lectin Bandeiraea simplicifolia I-isolectin B(4) (BSI-B(4)) to sensory neurones in seven mammalian species.
lectin Binding (binding) of
5) Confidence 0.12 Published 2002 Journal Anat. Rec. Section Abstract Doc Link 12221716 Disease Relevance 0 Pain Relevance 0.03
The plant lectin, IB4, binds to primary afferent neurons of dorsal root and trigeminal ganglia, where it is selective for nociceptive neurons.
lectin Binding (binds) of in neurons associated with nociception
6) Confidence 0.04 Published 2006 Journal J. Mol. Histol. Section Abstract Doc Link 16773225 Disease Relevance 0.10 Pain Relevance 0.08
Most unmyelinated nociceptive neurons that mediate pain and temperature sensation from the skin bind isolectin B4 (IB4)-lectin and express Ret, the common signaling component of glial cell line-derived neurotrophic factor (GDNF) family.
lectin Binding (bind) of in skin associated with nociception, pain and unmyelinated
7) Confidence 0.04 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16481427 Disease Relevance 0.35 Pain Relevance 0.32
The lectin pathway is initiated by recognition of exposed carbohydrates/ligands by mannose-binding lectin (MBL) and/or ficolins (Figure 1 (Fig. 1)) [10], [11].
lectin Binding (recognition) of
8) Confidence 0.04 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.59 Pain Relevance 0.14
Crosslinking of a specific population of flagellar surface-exposed glycoproteins with the lectin concanavalin A or an anti-carbohydrate mouse monoclonal antibody, designated FMG-1, results in a characteristic pattern of glycoprotein redistribution within the plane of the flagellar membrane.
lectin Binding (Crosslinking) of
9) Confidence 0.01 Published 1990 Journal J. Cell. Sci. Section Abstract Doc Link 2373742 Disease Relevance 0 Pain Relevance 0
With regard to the apoptotic effect of lectin–sugar interactions on the cell membrane, the question arises as to whether this is only an in vitro phenomenon or whether it has therapeutic relevance.
lectin Binding (interactions) of associated with apoptosis
10) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.68 Pain Relevance 0.14
Intestinal loops of approximately four cm containing a single PP were constricted and inoculated with 200 µg CPMV-AF488 and 20 µg UEA Rhodamine (Vector Laboratories) M cell binding lectin in a PBS solution of 450 µl total volume.
lectin Binding (binding) of in M cell
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.09
Ileal loops containing a single PP were injected into the intestinal lumen with 200 µg of CPMV-AF488 and 20 µg UEA rhodamine, a lectin that specifically binds to M cells.
lectin Binding (binds) of in M cells
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
Other constitiuents of plant extracts such as viscotoxins (2,3), poly- and oligosaccharides (4), flavonoids (5,6), chitin-binding mistletoe lectin (7) and arginine have also been investigated in connection with the effects of mistletoe extracts on the host defense.
lectin Binding (binding) of in poly
13) Confidence 0.01 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.14 Pain Relevance 0
Mice were intracranially infected, sacrificed after different times PI, and brain sections analyzed for lectin specific binding.
lectin Spec (analyzed) Binding (binding) of in brain
14) Confidence 0.01 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.42 Pain Relevance 0.08
In summary, these experiments confirm that the GCs detected by lectin binding are released by M. corti and this material is phagocytosed by host cells including areas in which parasites were absent.


lectin Binding (binding) of
15) Confidence 0.01 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.42 Pain Relevance 0
Many but not all ret-positive cells lose trkA expression postnataly and bind the lectin, Griffonia simplicifolia isolectin B4 Postnatally, neurons coexpressing ret and trkA, as analysed by double ISH, undergo trkA extinction, which appears to be complete at P14 (Luo et al. 2007).
lectin Spec (analysed) Binding (bind) of in neurons
16) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.08
Peanut lectin-binding GCs, in contrast, remained on the parasite and were not detected in host cells.
lectin Binding (binding) of
17) Confidence 0.01 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2274955 Disease Relevance 0.86 Pain Relevance 0.07
The Mannan-binding lectin complex is closely homologous to C1q and can activate C2 and C4[50].
lectin Binding (binding) of
18) Confidence 0.00 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.06 Pain Relevance 0

General Comments

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