INT230957

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.88
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CALD1) plasma membrane (CALD1) cytoskeleton (CALD1)
cytoplasm (CALD1)
Anatomy Link Frequency
myometrium 4
muscle 1
CALD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thoracotomy 1 80.24 Quite High
Glutamate receptor 5 63.92 Quite High
Neurotransmitter 6 60.20 Quite High
headache 1 57.24 Quite High
Angina 1 54.36 Quite High
Glutamate 6 41.36 Quite Low
agonist 8 38.08 Quite Low
bDMF 1 37.80 Quite Low
antagonist 8 35.28 Quite Low
Mechanotransduction 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 28 99.74 Very High Very High Very High
Adhesions 237 99.00 Very High Very High Very High
Lymphadenopathy 1 94.12 High High
Solitary Fibrous Tumors 1 92.56 High High
Pre-term Labor 30 84.84 Quite High
Respiratory Sounds 1 68.76 Quite High
Common Cold 1 62.32 Quite High
Dyspnea 1 59.72 Quite High
Hemoptysis 1 58.76 Quite High
Cough 2 58.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry revealed the tumor cells to be positive for CD 34, h-caldesmon (muscle marker) and focally positive for epithelial membrane antigen.
Positive_regulation (positive) of caldesmon in muscle associated with cancer
1) Confidence 0.45 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2409332 Disease Relevance 1.02 Pain Relevance 0.15
Thus, whereas increases in caldesmon levels suppress human myometrium contractility during pregnancy, stretch-dependent focal adhesion signaling, facilitated by the ERK activator SmAV, can contribute to myometrial activation.
Positive_regulation (increases) of caldesmon in myometrium associated with adhesions
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.48 Pain Relevance 0
Our data are consistent with the hypothesis that the observed increased inhibitory caldesmon protein content in human myometrium leads to a decreased contractile responsiveness to Ca during pregnancy.
Positive_regulation (increased) of caldesmon in myometrium
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
In myometrial samples collected from pregnant women who underwent Cesarean sections or non-pregnant women who underwent gynecological procedures, we confirmed the earlier reports of Word et al [13] and Riley et al [14] that h-CaD protein expression levels increase significantly during pregnancy (26907±3535 in ?
Positive_regulation (increase) of h-CaD
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
In contrast, genes expressed naturally by BM-MSC were downregulated after neurogenic induction (HAPLN1, CSPG4, CALD1, VIM, DSC96, MEST, TUFT1).


Positive_regulation (induction) of CALD1
5) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.05 Pain Relevance 0.09
Here we demonstrate that the Ca requirement for activation of the contractile filaments in human myometrium increases with caldesmon protein content during gestation and that an increase in caldesmon phosphorylation can reverse this inhibitory effect during labor.
Positive_regulation (increases) of caldesmon in myometrium
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.32 Pain Relevance 0
Stretch of human myometrium causes increased ERK activation and h-CaD phosphorylation
Positive_regulation (activation) of h-CaD in myometrium
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0

General Comments

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