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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A4)
Anatomy Link Frequency
extracellular matrix 2
body 1
COL4A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 8 84.48 Quite High
metalloproteinase 2 73.76 Quite High
Pain 2 55.96 Quite High
cva 6 50.20 Quite High
Chronic pancreatitis 13 30.48 Quite Low
Neurotransmitter 6 27.92 Quite Low
bDMF 1 6.88 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 67 98.24 Very High Very High Very High
Corneal Disease 23 98.18 Very High Very High Very High
Rupture 4 91.68 High High
Nicotine Addiction 10 84.00 Quite High
Obesity 3 83.84 Quite High
Cancer 28 78.48 Quite High
Osteoporosis 2 75.20 Quite High
Astigmatism 1 71.40 Quite High
Edema 6 68.32 Quite High
Aging 1 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, corneas with keratoconus are characterized by upregulation of various enzymes related to remodeling of the ECM and downregulation of genes encoding collagen type IV, laminin, and fibronectin; these downregulated genes encode for the molecules responsible for cell attachment in various basement membranes throughout the body [9-11].
Negative_regulation (downregulation) of collagen type IV in body associated with corneal disease
1) Confidence 0.14 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843708 Disease Relevance 0.88 Pain Relevance 0.12
Molecularly, the SPARC protein binds to a number of different extracellular matrix components, such as thrombospondin 1, vitronectin, entactin/nidogen, fibrillar collagens (types I, II, III, and V), and collagen type IV.
Negative_regulation (number) of collagen type IV in extracellular matrix
2) Confidence 0.03 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 1.25 Pain Relevance 0.04
Differentiated cells were not able to mineralize the matrix due to the important decreased of TUFT1, COL IV, V, XI, XII, OSF-2 and the modification of the extracellular matrix component after the differentiation (CSPG4, HAPLN1, ECM2, FN1).
Negative_regulation (decreased) of COL IV in extracellular matrix
3) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.53 Pain Relevance 0

General Comments

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