INT231266

Context Info Confidence 0.08 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 3.95 Pain Relevance 1.02

Anatomy Link Frequency lymphocytes 1 brain 1 dorsal root ganglia 1 kidney 1 Prh1 (Mus musculus)

Pain Link Frequency Relevance Heat potassium channel 18 99.96 Action potential 9 99.08 TRP channel 1 97.50 Hippocampus 2 85.68 cytokine 29 85.24 imagery 28 84.64 Serotonin 4 77.84 ischemia 4 76.28 cINOD 8 64.32 sodium channel 11 64.00

Disease Link Frequency Relevance Heat Targeted Disruption 29 97.42 Polycystic Kidney Disease 2 96.00 Viral Infection 7 92.84 Schizophrenia 10 92.68 Disease 129 91.84 Cataract 1 89.84 Glaucoma 1 89.44 Muscular Dystrophy 4 87.12 Cardiomyopathy 4 85.36 Premature Aging 4 77.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, it implies the possibility that A-type lamin expression in non-hematopoietic cells influences the function and development of these lymphocytes.

Gene_expression (expression) of A-type in lymphocytes

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.07

This implies that A-type lamin function/expression is not required in these cell types for normal development and homeostasis.

Gene_expression (expression) of A-type

2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.08

One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C.

Gene_expression (produce) of A-type

3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.52 Pain Relevance 0

One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C.

Gene_expression (produce) of A-type

4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.53 Pain Relevance 0

Specifically, Kcnip4 modulates A-type potassium channels and has been shown to increase expression of cardiac A-type Kv-4 channels [31].

Gene_expression (expression) of A-type associated with potassium channel

5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.53 Pain Relevance 0.29

Specifically, Kcnip4 modulates A-type potassium channels and has been shown to increase expression of cardiac A-type Kv-4 channels [31].

Gene_expression (modulates) of A-type associated with potassium channel

6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.60 Pain Relevance 0.28

In addition to examining this RNA sample for the presence of Hoxc11-specific transcripts, we determined whether there was evidence for expression of the remaining AbdB-type Hoxc genes (Hoxc9, Hoxc10, Hoxc12, and Hoxc13), as well as for the Hoxc11 and Hoxc10 paralogous genes (Hoxa11, Hoxd11, and Hoxa10, Hoxd10).

Gene_expression (expression) of AbdB-type

7) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570687 Disease Relevance 0.06 Pain Relevance 0

Polycystic kidney disease 2-like 1 (PKD2L1) and polycystic kidney disease 1-like 3 (PKD1L3), two members of the transient receptor potential channel family, have been identified in a subset of TCs distinct from sweet, umami or bitter cells [2] and PKD2L1-positive cells co-express various Type III cell marker proteins [9]–[12].

Gene_expression (express) of Type in kidney associated with trp channel and polycystic kidney disease

8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.24 Pain Relevance 0.15

B type lamins are essential, while the A-type lamins are believed to be non-essential and are only expressed in differentiated cells (Foisner, 2001).

Gene_expression (expressed) of A-type

9) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.41 Pain Relevance 0

It is worth noting that these risk alleles at the NRG1 locus also have been associated with increased expression of Type I and IV Nrg1 (Law et al., 2006).

Gene_expression (expression) of Type

10) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.32 Pain Relevance 0.04

Subsets of primary sensory neurons within the dorsal root ganglia (DRG) express Type III Nrg1 and ?

Gene_expression (express) of Type in dorsal root ganglia

11) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

Various transgenic mice have been generated, such as mice over expressing Rab9, a protein involved in intracellular trafficking [131-133], or mice expressing NPC1 only in one particular brain cell type [134].

Gene_expression (expressing) of type in brain associated with targeted disruption

12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.33 Pain Relevance 0.11

Cell type-specific overexpression can also be achieved by infecting a Cre-expressing mouse line with a virus where a flox-stop cassette precedes the gene of interest.

Gene_expression (overexpression) of type

13) Confidence 0.01 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.42 Pain Relevance 0

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