INT231276

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Erbb4, Nrg1) plasma membrane (Erbb4, Nrg1) mitochondrion (Erbb4)
cell morphogenesis (Nrg1) cell proliferation (Nrg1) signal transduction (Erbb4)
Erbb4 (Mus musculus)
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 69.68 Quite High
Nicotine 12 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Somatosensory cortex 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malformations Of Cortical Development 7 60.64 Quite High
Disseminated Intravascular Coagulation 10 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of presynaptic Type III Nrg1 signaling, either by postsynaptic ErbB4 (as shown in Fig.
ErbB4 Positive_regulation (Activation) of Nrg1
1) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.03
We further investigated the effects induced by reelin and found that signaling was mediated via VLDLR/Dab1/Pi3K activation while NRG1 signaling was mediated via erbB3/erbB4/Pi3K.
erbB4 Positive_regulation (mediated) of NRG1
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0

General Comments

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