INT231304

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prnp, Grin2d) transport (Grin2d) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) nucleolus (Prnp) nucleus (Prnp)
Anatomy Link Frequency
neurons 1
Prnp (Mus musculus)
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 16 97.76 Very High Very High Very High
Neuronal excitability 7 96.56 Very High Very High Very High
nMDA receptor 7 89.32 High High
Hippocampus 22 82.64 Quite High
Glutamate receptor 1 47.88 Quite Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 25 85.96 High High
Death 23 83.36 Quite High
Viral Meningitis 1 72.00 Quite High
Alzheimer's Dementia 2 71.52 Quite High
Disease 8 63.60 Quite High
Sprains And Strains 11 26.88 Quite Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Prion Diseases 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, native PrPC mediates an important neuroprotective role by virtue of its ability to inhibit NR2D subunits.



PrPC Negative_regulation (inhibit) of NR2D
1) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.17
Although we did not explore NR2D levels in the present study, it has recently been described that PrPc inhibits NR2D subunits [57], thus PrPc-deficient neurons showed enhanced and drastically prolonged NMDA-evoked currents [57].
PrPc Negative_regulation (inhibits) of NR2D in neurons
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2763346 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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