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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pla2g4a, Pla2g6) cytosol (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) nucleus (Pla2g4a) lipid metabolic process (Pla2g6)
Anatomy Link Frequency
reticulum 1
Pla2g4a (Mus musculus)
Pla2g6 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 28 89.20 High High
Pain 34 86.00 High High
Spinal cord 11 85.28 High High
Sciatic nerve 11 81.24 Quite High
substance P 11 67.60 Quite High
Glutamate 2 66.96 Quite High
Neuropathic pain 52 66.56 Quite High
cytokine 1 56.56 Quite High
allodynia 20 53.76 Quite High
Thermal hyperalgesia 3 52.76 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 31 89.20 High High
Pain 42 86.00 High High
Nervous System Injury 28 81.52 Quite High
Injury 15 72.24 Quite High
Neuropathic Pain 79 66.56 Quite High
Nociception 28 60.04 Quite High
Hyperalgesia 10 52.76 Quite High
Ganglion Cysts 8 17.88 Low Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies revealed that phosphatidyl choline is converted to LPC by cytosolic phospholipase A2 (cPLA2) or calcium-independent PLA2 (iPLA2), both of which are regulated by Ca2+-related mechanisms. cPLA2 is activated through membrane translocation, which is stimulated by Ca2+ or phosphorylation by mitogen-activated kinase (MAPK) or PKCs [76-78], while iPLA2 is activated through the removal of calmodulin by calcium influx factor (CIF) produced after Ca2+ depletion in the endoplasmic reticulum [79,80].
cPLA2 Regulation (regulated) of iPLA2 in reticulum
1) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 0.92 Pain Relevance 0.77

General Comments

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