INT23148

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Context Info
Confidence 0.10
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.58
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1)
transcription factor binding (RUNX1)
Anatomy Link Frequency
hepatocytes 1
RUNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 98.24 Very High Very High Very High
Kinase C 36 97.88 Very High Very High Very High
agonist 5 97.76 Very High Very High Very High
Clonidine 1 95.60 Very High Very High Very High
Inflammation 16 93.52 High High
Pain 17 92.84 High High
imagery 117 92.24 High High
bradykinin 5 85.96 High High
abatacept 123 83.32 Quite High
rheumatoid arthritis 42 81.60 Quite High
Disease Link Frequency Relevance Heat
Precursor Cell Lymphoblastic Leukemia-lymphoma 56 100.00 Very High Very High Very High
Myeloid Leukemia 46 100.00 Very High Very High Very High
Acute Myeloid Leukemia 27 100.00 Very High Very High Very High
Adenocarcinoma 4 99.28 Very High Very High Very High
Aneuploidy 7 99.10 Very High Very High Very High
Leukemia 105 97.94 Very High Very High Very High
Hepatitis B Virus Infection 1 97.84 Very High Very High Very High
Metastasis 46 96.72 Very High Very High Very High
Infection 78 96.68 Very High Very High Very High
Breast Cancer 28 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AML transformation (March 2002)
Gene_expression (transformation) of AML associated with myeloid leukemia
1) Confidence 0.10 Published 2007 Journal Ulster Med J Section Body Doc Link PMC2075573 Disease Relevance 0.89 Pain Relevance 0
There was therefore evidence of the same aneuploidy involving chromosomes 13 and 15 detected at AML transformation.


Gene_expression (transformation) of AML associated with aneuploidy and myeloid leukemia
2) Confidence 0.10 Published 2007 Journal Ulster Med J Section Body Doc Link PMC2075573 Disease Relevance 0.96 Pain Relevance 0
This ligand activation profile was not affected over a 30-fold range of expression of the fusion protein in contrast to the observed enhancement of the partial agonists' maximal responses by co-expression of the alpha2A-adrenoceptor with increasing amounts of the G alpha15 protein.
Gene_expression (expression) of fusion protein associated with agonist
3) Confidence 0.04 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882043 Disease Relevance 0 Pain Relevance 0.26
A CTLA4-Ig fusion protein was initially applied in rodent models of transplantation [14], in which graft survival was prolonged.
Gene_expression (applied) of fusion protein
4) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.86 Pain Relevance 0.28
Mammary adenocarcinoma cells were genetically modified to express a fusion protein of green fluorescent protein (GFP) and the chemokine receptor CXCR4, which is implicated in metastasis of many types of cancer [97, 98].
Gene_expression (express) of fusion protein associated with adenocarcinoma, chemokine, cancer and metastasis
5) Confidence 0.02 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.85 Pain Relevance 0.28
to a monomeric red fluorescent protein (mRFP1) and introduced this fusion protein into the mammary cells already stably expressing CXCR4-GFP.
Gene_expression (introduced) of fusion protein
6) Confidence 0.02 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.83 Pain Relevance 0.38
In a review by Savitz and Chen (1990) of seven published epidemiologic studies of the association between parental occupation and childhood leukemia, exposure to paints and pigments yielded the most consistently positive results, with several studies producing ORs for ALL and AML of ?
Gene_expression (producing) of AML associated with leukemia, precursor cell lymphoblastic leukemia-lymphoma and acute myeloid leukemia
7) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817663 Disease Relevance 0.75 Pain Relevance 0
To examine the validity of the strategy to express a foreign gene as a fusion protein with the coat protein (CP) of tobacco mosaic virus (TMV), we have constructed ENK RNA by using an in vitro transcription system of TMV RNA.
Gene_expression (express) of fusion protein
8) Confidence 0.01 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2387417 Disease Relevance 0 Pain Relevance 0.16
The recombinant receptor was produced as a fusion protein with affinity tags and an expression level of 11 pmol/mg (i.e., approx. 0.2 mg of active receptor per liter of culture) was obtained.
Gene_expression (produced) of fusion protein
9) Confidence 0.01 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.19 Pain Relevance 0.34
It was recently demonstrated that the KgBpK-gC- virus, further modified to express and incorporate a fusion protein between gC and the preS1 active peptide (preS1ap) of HBV, was able to bind preferentially to hepatocytes, giving a productive infection [253].
Gene_expression (express) of fusion protein in hepatocytes associated with hepatitis b virus infection and infection
10) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.25 Pain Relevance 0

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