INT23148

Context Info Confidence 0.10 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 6.58 Pain Relevance 1.71

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1) transcription factor binding (RUNX1)

Anatomy Link Frequency hepatocytes 1 RUNX1 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 11 98.24 Kinase C 36 97.88 agonist 5 97.76 Clonidine 1 95.60 Inflammation 16 93.52 Pain 17 92.84 imagery 117 92.24 bradykinin 5 85.96 abatacept 123 83.32 rheumatoid arthritis 42 81.60

Disease Link Frequency Relevance Heat Precursor Cell Lymphoblastic Leukemia-lymphoma 56 100.00 Myeloid Leukemia 46 100.00 Acute Myeloid Leukemia 27 100.00 Adenocarcinoma 4 99.28 Aneuploidy 7 99.10 Leukemia 105 97.94 Hepatitis B Virus Infection 1 97.84 Metastasis 46 96.72 Infection 78 96.68 Breast Cancer 28 96.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AML transformation (March 2002)

Gene_expression (transformation) of AML associated with myeloid leukemia

1) Confidence 0.10 Published 2007 Journal Ulster Med J Section Body Doc Link PMC2075573 Disease Relevance 0.89 Pain Relevance 0

There was therefore evidence of the same aneuploidy involving chromosomes 13 and 15 detected at AML transformation.

Gene_expression (transformation) of AML associated with aneuploidy and myeloid leukemia

2) Confidence 0.10 Published 2007 Journal Ulster Med J Section Body Doc Link PMC2075573 Disease Relevance 0.96 Pain Relevance 0

This ligand activation profile was not affected over a 30-fold range of expression of the fusion protein in contrast to the observed enhancement of the partial agonists' maximal responses by co-expression of the alpha2A-adrenoceptor with increasing amounts of the G alpha15 protein.

Gene_expression (expression) of fusion protein associated with agonist

3) Confidence 0.04 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882043 Disease Relevance 0 Pain Relevance 0.26

A CTLA4-Ig fusion protein was initially applied in rodent models of transplantation [14], in which graft survival was prolonged.

Gene_expression (applied) of fusion protein

4) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.86 Pain Relevance 0.28

Mammary adenocarcinoma cells were genetically modified to express a fusion protein of green fluorescent protein (GFP) and the chemokine receptor CXCR4, which is implicated in metastasis of many types of cancer [97, 98].

Gene_expression (express) of fusion protein associated with adenocarcinoma, chemokine, cancer and metastasis

5) Confidence 0.02 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.85 Pain Relevance 0.28

to a monomeric red fluorescent protein (mRFP1) and introduced this fusion protein into the mammary cells already stably expressing CXCR4-GFP.

Gene_expression (introduced) of fusion protein

6) Confidence 0.02 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.83 Pain Relevance 0.38

In a review by Savitz and Chen (1990) of seven published epidemiologic studies of the association between parental occupation and childhood leukemia, exposure to paints and pigments yielded the most consistently positive results, with several studies producing ORs for ALL and AML of ?

Gene_expression (producing) of AML associated with leukemia, precursor cell lymphoblastic leukemia-lymphoma and acute myeloid leukemia

7) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817663 Disease Relevance 0.75 Pain Relevance 0

To examine the validity of the strategy to express a foreign gene as a fusion protein with the coat protein (CP) of tobacco mosaic virus (TMV), we have constructed ENK RNA by using an in vitro transcription system of TMV RNA.

Gene_expression (express) of fusion protein

8) Confidence 0.01 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2387417 Disease Relevance 0 Pain Relevance 0.16

The recombinant receptor was produced as a fusion protein with affinity tags and an expression level of 11 pmol/mg (i.e., approx. 0.2 mg of active receptor per liter of culture) was obtained.

Gene_expression (produced) of fusion protein

9) Confidence 0.01 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.19 Pain Relevance 0.34

It was recently demonstrated that the KgBpK-gC- virus, further modified to express and incorporate a fusion protein between gC and the preS1 active peptide (preS1ap) of HBV, was able to bind preferentially to hepatocytes, giving a productive infection [253].

Gene_expression (express) of fusion protein in hepatocytes associated with hepatitis b virus infection and infection

10) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.25 Pain Relevance 0

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