INT231573

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 7.94
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PTPN22) cytoplasm (PTPN22)
Anatomy Link Frequency
juvenile 1
PTPN22 (Homo sapiens)
PTPN22 - R620W (1)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 87 99.76 Very High Very High Very High
Arthritis 83 98.86 Very High Very High Very High
Multiple sclerosis 6 98.12 Very High Very High Very High
Crohn's disease 32 97.80 Very High Very High Very High
spinal inflammation 111 94.88 High High
Inflammation 25 86.08 High High
psoriasis 8 83.36 Quite High
spondylitis 4 50.00 Quite Low
cytokine 6 43.80 Quite Low
chemokine 4 33.20 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 32 100.00 Very High Very High Very High
Rheumatoid Arthritis 90 99.76 Very High Very High Very High
Thyroiditis 2 99.40 Very High Very High Very High
Juvenile Chronic Polyarthritis 72 98.86 Very High Very High Very High
Diabetes Mellitus 16 98.40 Very High Very High Very High
Systemic Lupus Erythematosus 4 98.28 Very High Very High Very High
Disease 118 98.20 Very High Very High Very High
Demyelinating Disease 6 98.12 Very High Very High Very High
Uveitis 118 97.00 Very High Very High Very High
Ankylosing Spondylitis 84 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A notable example of this is the association of PTPN22 with several autoimmune conditions including RA, T1D, CD and SLE.
PTPN22 Binding (association) of associated with crohn's disease, diabetes mellitus, rheumatoid arthritis and systemic lupus erythematosus
1) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 1.56 Pain Relevance 0.50
The three most important SNPs for the prediction were PTPN22*rs2476601, MAP3K71P2*rs577001, and RUNX1*rs2268277.
PTPN22 Binding (rs2476601) of
2) Confidence 0.36 Published 2007 Journal BMC Proc Section Body Doc Link PMC2367463 Disease Relevance 0.29 Pain Relevance 0.11
In conclusion, the lack of association between SNPs in the genetic master switches of autoimmunity, PTPN22 and CTLA-4, suggests that regardless of the strong linkage with HLA-B*27, AAU should be regarded as an autoinflammatory rather than an autoimmune condition.



PTPN22 Binding (association) of associated with autoimmune disease and uveitis
3) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 1.07 Pain Relevance 0.05
For example, variants in PTPN22 are associated with rheumatoid arthritis (RA), type-1-diabetes (T1D) and Crohn's disease (CD).
PTPN22 Binding (associated) of associated with crohn's disease, diabetes mellitus, rheumatoid arthritis and disease
4) Confidence 0.34 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 2.25 Pain Relevance 0.94
In juvenile idiopathic arthritis (JIA), another complex genetic autoimmune disease, the strategy of using information from autoimmune disease GWAS or candidate gene studies to help in the search for novel JIA susceptibility loci has been successful, with confirmed association with two genes, PTPN22 and IL2RA.
PTPN22 Binding (association) of in juvenile associated with autoimmune disease, juvenile chronic polyarthritis and arthritis
5) Confidence 0.34 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2935325 Disease Relevance 1.86 Pain Relevance 0.62
In contrast, PTPN22 R620W has not been associated with two other presumed autoimmune disorders, multiple sclerosis and Crohn’s disease [7,8].
PTPN22 (R620W) Binding (associated) of associated with multiple sclerosis, autoimmune disease and disease
6) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.91 Pain Relevance 0.10

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