INT231639

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.19

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2) protein complex (PTGS2) cytoplasm (PTGS2) signal transducer activity (PTGER2)

PTGER2 (Homo sapiens) PTGS2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 88.16 Pain 1 83.28 Inflammatory response 1 77.68 agonist 3 5.00 alcohol 2 5.00 COX2 1 5.00 COX-2 inhibitor 1 5.00 Kinase C 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 7 88.16 Pain 1 83.28 Increased Venous Pressure Under Development 1 82.80 Hyperplasia 1 55.20 Cancer 3 42.32 Necrosis 1 5.00 Autoimmune Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PGH2 can be isomerized in PGE2, either non-enzymatically [9], or by the microsomal PGE2 synthase (mPGES)-1 isoform [8], while formation of TXA2 chiefly results from TXA2 synthase activity.

PGE2 Binding (isomerized) of PGH2

1) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0.44 Pain Relevance 0.19

General Comments

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