INT2317

Context Info Confidence 0.58 First Reported 1977 Last Reported 1993 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.35 Pain Relevance 0.68

endoplasmic reticulum (Ugt1a5)

Anatomy Link Frequency bile duct 1 1A2 1 Ugt1a5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 1 99.44 Paracetamol 7 93.60 Morphine 3 90.56 dexamethasone 3 80.28 Analgesic 1 40.80

Disease Link Frequency Relevance Heat Jaundice 2 95.00 Pox Virus Infection 1 91.60 Hyperbilirubinemia 1 72.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, injection of bilirubin at subtoxic doses using a variety of regimens failed to produce detectable activation of UDPGT in intact or bile duct-ligated rats.

Neg (failed) Gene_expression (produce) of UDPGT in bile duct associated with bile

1) Confidence 0.58 Published 1977 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 403586 Disease Relevance 0.25 Pain Relevance 0.28

Of these, P450 2E1, 1A2, and 3A4 showed substantial activity, with respective Km and Vmax values of 680 microM and 330 pmol/(min.mg) for P450 2E1 (with added cytochrome b5), 3430 microM and 74 pmol/(min.mg) for P450 1A2, and 280 microM and 130 pmol/(min.mg) for P450 3A4.

Gene_expression (with) of b5 in 1A2

2) Confidence 0.34 Published 1993 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8374050 Disease Relevance 0.09 Pain Relevance 0.40

General Comments

This test has worked.