INT231749

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Revision as of 17:45, 20 September 2012 by Daniel (Talk | contribs)

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.98
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Th17 cells 1
Cia1 (Mus musculus)
LOC690550 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 51 100.00 Very High Very High Very High
Inflammation 13 97.64 Very High Very High Very High
cytokine 15 93.88 High High
rheumatoid arthritis 24 65.72 Quite High
antagonist 3 15.84 Low Low
methotrexate 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 54 100.00 Very High Very High Very High
INFLAMMATION 15 97.64 Very High Very High Very High
Autoimmune Disease 1 95.20 Very High Very High Very High
Disease 26 80.16 Quite High
Rheumatoid Arthritis 24 65.72 Quite High
Disease Progression 1 41.28 Quite Low
Pressure And Volume Under Development 15 5.00 Very Low Very Low Very Low
Erythema 5 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it is possible that CP-690550, through inhibition of IL-21R signaling, may also be efficacious in the CIA model by reducing IL-17 producing Th17 cells which have been proposed to play an important role in the pathogenesis of autoimmune diseases.
CIA Binding (efficacious) of CP-690550 in Th17 cells associated with autoimmune disease and arthritis
1) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.98 Pain Relevance 0.43

General Comments

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