INT23199

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 17.08
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
blood 3
plasma 2
macrophages 1
circulating cell 1
liver 1
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 9 98.90 Very High Very High Very High
depression 10 98.72 Very High Very High Very High
rheumatoid arthritis 117 96.52 Very High Very High Very High
Angina 21 95.88 Very High Very High Very High
Multiple sclerosis 2 93.56 High High
Inflammatory marker 3 82.88 Quite High
dexamethasone 92 80.56 Quite High
Inflammation 46 73.60 Quite High
cytokine 10 70.32 Quite High
Central nervous system 7 50.92 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 692 100.00 Very High Very High Very High
Diabetes Mellitus 190 100.00 Very High Very High Very High
Obesity 65 100.00 Very High Very High Very High
Atherosclerosis 58 100.00 Very High Very High Very High
Cardiovascular Disease 159 99.76 Very High Very High Very High
Disease 201 99.34 Very High Very High Very High
Depression 13 98.72 Very High Very High Very High
Hyperlipidemia 45 98.14 Very High Very High Very High
Acute Coronary Syndrome 76 97.56 Very High Very High Very High
Adhesions 45 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also have found that the IRPI binding activity for the FHC IRE is modestly downregulated by iron at high doses administered for 18 hours.
FHC Binding (activity) of in FHC
1) Confidence 0.47 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.24 Pain Relevance 0
The clinical diagnosis, homozygous familial hypercholesterolaemia, was confirmed by: (1) investigation of the family revealing hypercholesterolaemia in both her parents and siblings; (2) fibroblast association studies, in which the specific association of low density lipoprotein (LDL) was 35% of normal; and (3) LDL turnover study, in which the fractional catabolic rate of LDL was decreased to 0.213 pools/day.
low density lipoprotein Binding (association) of in fibroblast associated with hyperlipidemia
2) Confidence 0.36 Published 1990 Journal Neth J Med Section Abstract Doc Link 2395495 Disease Relevance 0.62 Pain Relevance 0.05
Bovine aortic endothelial and smooth muscle cells (SMC) and human skin fibroblasts (HSF) were used to study the effect of verapamil on cellular interactions with human low density lipoprotein (LDL).
low density lipoprotein Binding (interactions) of in SMC
3) Confidence 0.29 Published 1985 Journal Arteriosclerosis Section Abstract Doc Link 3966907 Disease Relevance 0 Pain Relevance 0
As it is bound to low density lipoprotein (LDL), it binds predominantly to cells with high metabolic activity such as endothelial cells of newly formed vessels.
low density lipoprotein Binding (bound) of in vessels
4) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697459 Disease Relevance 0.68 Pain Relevance 0
The different rates of uptake of CRLPs oxCRLPs and pCRLPs by macrophages demonstrated here, therefore, could be explained by effects on interaction with the LDLr and the LRP caused by differences both in the conformation of apoE and in the number of apoE molecules able to bind to the receptors, even though the total amount of apoE associated with the particles is not changed.
LDLr Binding (interaction) of in macrophages
5) Confidence 0.24 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0 Pain Relevance 0
ApoB is also essential for the binding of LDL particles to the LDL receptor for cellular uptake and degradation of LDL particles (Simon et al. 2005).
LDL receptor Binding (binding) of
6) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0
This phenotype is considered to be of particular importance in the pathogenesis of atherosclerosis, since these LDL bind less avidly to the LDL receptor which mediates its endocytosis in the liver or peripheral tissues (Liu and Rosner, 2006).
LDL receptor Binding (bind) of in liver associated with atherosclerosis
7) Confidence 0.22 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.02 Pain Relevance 0.10
After adjusting for sociodemographic characteristics, duration of diabetes, diabetes education, depression, alcohol use, and medication use we did not find a significant association between literacy and glycemic control (beta coefficent,+ 0.001; 95% confidence interval [CI], -0.01 to +0.01; P = .88), systolic blood pressure (beta coefficent, +0.08; 95% CI, -0.10 to +0.26; P = .39), diastolic blood pressure (beta coefficent, -0.03; 95% CI, -0.12 to +0.07, P = .59), or low density lipoprotein (beta coefficent, +0.04; 95% CI, -0.27 to +0.36, P = .77.
low density lipoprotein Neg (not) Binding (association) of in blood associated with depression, diabetes mellitus and alcohol
8) Confidence 0.22 Published 2006 Journal BMC Fam Pract Section Abstract Doc Link PMC1559691 Disease Relevance 0.97 Pain Relevance 0.10
Treatment with fenofibrate shifts the ratio of LDL-C particle subspecies from small, dense, atherogenic LDL particles (LDL 4 and LDL 5) to large, buoyant ones (LDL 3).54 These larger, less dense LDL particles show higher affinity for the LDL receptor, while an association between small dense LDL and increased CVD risk has long been established.
LDL 4 Binding (affinity) of associated with cardiovascular disease
9) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.40 Pain Relevance 0
Treatment with fenofibrate shifts the ratio of LDL-C particle subspecies from small, dense, atherogenic LDL particles (LDL 4 and LDL 5) to large, buoyant ones (LDL 3).54 These larger, less dense LDL particles show higher affinity for the LDL receptor, while an association between small dense LDL and increased CVD risk has long been established.
LDL receptor Binding (affinity) of associated with cardiovascular disease
10) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.36 Pain Relevance 0
This region contains the CD69-homologous amino acid sequence and one of the LDLR domains, which were thought to bind various ligands such as apolipoprotein E?
LDLR Binding (bind) of associated with disorder of lipid metabolism
11) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.48 Pain Relevance 0.04
It is thus tempting to speculate that these domains are crucial for the specific function of the receptors and that these receptors likely bind to lipoproteins or large protein complexes as ligands, analogous to the classical human LDL receptor.
LDL receptor Binding (bind) of
12) Confidence 0.10 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0
The role that ApoE isoforms play in disease development seems to be closely associated with different affinities of the various isoforms for the low density lipoprotein-receptor and lipids themselves.
low density lipoprotein-receptor Binding (associated) of associated with disease
13) Confidence 0.06 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 1.13 Pain Relevance 0.07
The observed rise of small dense LDL is important, in view of its association with cardiovascular disease in the general population.
small dense LDL Binding (association) of associated with cardiovascular disease
14) Confidence 0.06 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350142 Disease Relevance 1.35 Pain Relevance 0.28
Since the physiological role of ApoE is dependent binding of lipid and the LDL-receptor, these data suggest that the ApoE would satisfy its role in vivo.
LDL-receptor Binding (binding) of
15) Confidence 0.06 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.08
Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and concentrations of plasma lipids with high-density lipoprotein subclass distribution in the Chinese population

Background

low-density lipoprotein cholesterol Binding (Association) of in plasma
16) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Title Doc Link PMC2920871 Disease Relevance 1.12 Pain Relevance 0
ANOVA: analysis of variance; BMI: body mass index; BP: blood pressure; CAD: coronary artery disease; HDL: high-density lipoprotein; IDL: intermediate-density lipoprotein; LDL: low-density lipoprotein; NMR: nuclear magnetic resonance; sdLDL: small, dense LDL; TZD: thiazolidinedione; VLDL: very-low-density lipoprotein.


low-density lipoprotein Binding (thiazolidinedione) of in body associated with coronary artery disease, hypertension, obesity and disorder of lipid metabolism
17) Confidence 0.04 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2713234 Disease Relevance 0.96 Pain Relevance 0
The genotypes were not associated with gender, duration of diabetes, age, diabetes treatment, BMI, HbA1c and fasting blood glucose levels, SBP, DBP, serum levels of total cholesterol, triglycerides, HDL cholesterol, low-density lipoprotein (LDL) cholesterol and creatinine.
low-density lipoprotein Neg (not) Binding (associated) of in blood associated with diabetes mellitus, obesity and disorder of lipid metabolism
18) Confidence 0.04 Published 2006 Journal Diabetic Medicine Section Body Doc Link PMC1619898 Disease Relevance 1.90 Pain Relevance 0
The rationale behind maintaining high CsA blood concentration is to overcome the effect of high serum levels of low-density lipoprotein (LDL) (secondary to recurrent NS), which binds CsA and is further responsible for low levels of free available CsA.
low-density lipoprotein Binding (binds) of in blood associated with disorder of lipid metabolism
19) Confidence 0.03 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 0.44 Pain Relevance 0
For example, sd-LDL may reside in the plasma longer,6-10 not bind the LDL receptor as well, bind the scavenger receptor more avidly,11-14 be more susceptible to oxidation,15-17 have fewer antioxidants in its core,18,19 enter the arterial wall more easily,20,21 and bind to the glycosaminoglycans in the arterial wall more readily.22,23 The cellular mechanisms include: an sd-LDL promotion of endothelial cell dysfunction,24 induction of greater PAI-1 (plasminogen activator inhibitor-1) production in endothelial cells,25 an increase in thromboxane secretion in endothelial cells,26 and an increase in arterial smooth muscle intracellular calcium.27
LDL receptor Neg (not) Binding (bind) of in endothelial cells
20) Confidence 0.03 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688162 Disease Relevance 0.43 Pain Relevance 0

General Comments

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