INT232105

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SMPD2) plasma membrane (SMPD2)
Anatomy Link Frequency
Notch 1
SMPD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 16.96 Low Low
Kinase C 4 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 82 93.60 High High
Aging 24 88.84 High High
Intestinal Cancer 14 75.56 Quite High
Salivary Gland Disease 8 75.52 Quite High
Stress 28 56.60 Quite High
Ulcers 5 50.00 Quite Low
Alagille Syndrome 3 29.12 Quite Low
INFLAMMATION 2 16.96 Low Low
Cleidocranial Dysplasia 23 9.32 Low Low
Poisoning 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to abolish ISC function, we thus transiently expressed an activated form of Notch (IntraCellular Domain; NICD) in ISCs and EBs using the esgGal4 driver.
Negative_regulation (abolish) of ISC in Notch
1) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.70 Pain Relevance 0
Pretreatment of cells with SMase C visibly reduced VacA-mediated cellular vacuolation (Figure 1C).
Negative_regulation (reduced) of SMase
2) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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