INT232105

Context Info Confidence 0.42 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.70 Pain Relevance 0

small molecule metabolic process (SMPD2) plasma membrane (SMPD2)

Anatomy Link Frequency Notch 1 SMPD2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 16.96 Kinase C 4 5.00 tolerance 1 5.00 anesthesia 1 5.00 peptic ulcer disease 1 5.00

Disease Link Frequency Relevance Heat Lifespan 82 93.60 Aging 24 88.84 Intestinal Cancer 14 75.56 Salivary Gland Disease 8 75.52 Stress 28 56.60 Ulcers 5 50.00 Alagille Syndrome 3 29.12 INFLAMMATION 2 16.96 Cleidocranial Dysplasia 23 9.32 Poisoning 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In order to abolish ISC function, we thus transiently expressed an activated form of Notch (IntraCellular Domain; NICD) in ISCs and EBs using the esgGal4 driver.

Negative_regulation (abolish) of ISC in Notch

1) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.70 Pain Relevance 0

Pretreatment of cells with SMase C visibly reduced VacA-mediated cellular vacuolation (Figure 1C).

Negative_regulation (reduced) of SMase

2) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0 Pain Relevance 0

General Comments

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