INT23221

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.57
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
cerebellum 3
spinal cord 2
dorsal root ganglia 2
nasal mucosa 2
cortex 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 80 99.84 Very High Very High Very High
Spinal cord 32 99.68 Very High Very High Very High
Potency 8 99.58 Very High Very High Very High
intrathecal 28 98.96 Very High Very High Very High
c fibre 41 98.88 Very High Very High Very High
midbrain 2 98.68 Very High Very High Very High
antagonist 15 98.32 Very High Very High Very High
Inflammatory response 1 98.06 Very High Very High Very High
Somatosensory cortex 2 97.48 Very High Very High Very High
gABA 4 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 2 98.72 Very High Very High Very High
INFLAMMATION 20 97.88 Very High Very High Very High
Nociception 28 90.40 High High
Increased Venous Pressure Under Development 3 85.84 High High
Ganglion Cysts 37 85.08 High High
Pain 23 81.36 Quite High
Stress 1 74.80 Quite High
Heart Rate Under Development 1 52.52 Quite High
Hypersensitivity 11 50.56 Quite High
Overactive Bladder 1 6.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant specific [3H]RTX binding was also absent in membrane preparations of the midbrain central gray matter, somatosensory cortex and cerebellum either from naive or capsaicin treated rats.
Negative_regulation (absent) of RTX Binding (binding) of in cerebellum associated with somatosensory cortex, qutenza and midbrain
1) Confidence 0.37 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.66
The RTX-induced desensitization was not associated with loss of specific [3H]RTX binding, suggesting lack of gross cell toxicity.
Negative_regulation (loss) of RTX Binding (binding) of associated with toxicity
2) Confidence 0.14 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.28 Pain Relevance 0.69
Likewise, the competitive antagonist capsazepine inhibited RTX-induced desensitization with potency similar to that for inhibition of specific [3H]RTX binding, whereas the potency of capsazepine was approximately 10-fold higher for inhibiting RTX-induced 45Ca uptake.
Negative_regulation (inhibition) of RTX Binding (binding) of associated with antagonist and potency
3) Confidence 0.14 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.29 Pain Relevance 0.62
Significant specific [3H]RTX binding was also absent in membrane preparations of the midbrain central gray matter, somatosensory cortex and cerebellum either from naive or capsaicin treated rats.
Negative_regulation (absent) of RTX in cortex Binding (binding) of in cerebellum associated with somatosensory cortex, qutenza and midbrain
4) Confidence 0.13 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.66
The results also demonstrate that mid-plantar injection of RTX removes both A?
Negative_regulation (removes) of RTX Binding (injection) of
5) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.23 Pain Relevance 0.33
Typical phorbol esters did not inhibit [3H]RTX binding.
Negative_regulation (inhibit) of RTX Binding (binding) of
6) Confidence 0.11 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400923 Disease Relevance 0.07 Pain Relevance 0.56
In 1993, Goso et al., reported using receptor binding and neurogenic inflammatory response that RTX-induced loss of binding and extravasation were partly recovered in the bladder but the RTX binding was not recovered in the spinal cord after intrathecal administration [28].
Neg (not) Negative_regulation (recovered) of RTX Binding (binding) of in spinal cord associated with inflammatory response, intrathecal and spinal cord
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.34 Pain Relevance 0.69
In synaptic membranes of chronically treated rats we found a marked reduction in the protein-protein interaction between syntaxin 1 and Thr286-phosphorylated alphaCaM kinase II (alpha-calcium/calmodulin-dependent protein kinase II) (an interaction previously proposed to promote neurotransmitter release) and a marked increase in the interaction between syntaxin 1 and Munc-18 (an interaction proposed to reduce neurotransmitter release).
Negative_regulation (reduction) of Thr286-phosphorylated Binding (interaction) of associated with neurotransmitter
8) Confidence 0.02 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15800181 Disease Relevance 0.07 Pain Relevance 0.84
Interestingly, rabbits have been suggested to be insensitive to capsaicin and have been shown to lack detectable [(3)H]RTX binding in membranes prepared from their dorsal root ganglia.
Negative_regulation (lack) of RTX Binding (binding) of in dorsal root ganglia associated with qutenza
9) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14996838 Disease Relevance 0 Pain Relevance 0.21
Specific [3H]resiniferatoxin binding to nasal mucosa membranes was fully inhibited by capsaicin (Ki = 5 microM) and lactic acid (IC50 at pH 5.0) but not by capsazepine (up to 10 microM), in accord with the physiological findings.
Negative_regulation (inhibited) of resiniferatoxin Binding (binding) of in nasal mucosa associated with qutenza
10) Confidence 0.01 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8737969 Disease Relevance 0.29 Pain Relevance 0.70

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