INT232364

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Agxt) extracellular region (Bgn) proteinaceous extracellular matrix (Bgn)
peroxisome (Agxt)
Bgn (Mus musculus)
Agxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 3 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
eye pain 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 31 98.64 Very High Very High Very High
Brain Tumor 9 85.60 High High
Glioma 37 79.20 Quite High
Neurologic Manifestations 1 65.20 Quite High
Cyst 1 64.04 Quite High
Recurrence 7 57.36 Quite High
Necrosis 5 49.36 Quite Low
Glioblastoma 14 46.40 Quite Low
Hydrocephalus 3 40.04 Quite Low
Death 5 37.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial work in animal models showed that O6BG can potentiate the activity of carmustine wafers by inhibiting the activity of AGT, a DNA repair enzyme involved in tumor resistance to alkylating agents including BCNU, and prolong animal survival (Rhines et al 2000).
O6BG Negative_regulation (inhibiting) of AGT associated with cancer
1) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.65 Pain Relevance 0

General Comments

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