INT232386

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD22) nucleus (SYCP3) plasma membrane (CD22)
cell cycle (SYCP3) DNA binding (SYCP3) cell division (SYCP3)
Anatomy Link Frequency
B-cells 1
CD22 (Homo sapiens)
SYCP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 10 84.08 Quite High
corticosteroid 7 62.12 Quite High
methotrexate 2 61.32 Quite High
Antihistamine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 22 99.04 Very High Very High Very High
Systemic Lupus Erythematosus 23 85.84 High High
Rheumatoid Arthritis 10 84.08 Quite High
Disease 11 77.28 Quite High
Renal Disease 3 56.56 Quite High
Purpura 1 42.00 Quite Low
Syndrome 6 38.36 Quite Low
Lymphatic System Cancer 16 25.64 Quite Low
Proteinuria 1 7.28 Low Low
Vomiting 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, the CD22 molecule indigenous to B-cells has gained considerable attention as an important co-receptor in BCR function and in autoimmunity, and thus as a potential target for autoimmune therapy (Nitschke 2005; Tedder et al 2005a; Goldenberg 2006).


CD22 Binding (indigenous) of co-receptor in B-cells associated with autoimmune disease
1) Confidence 0.37 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.86 Pain Relevance 0.16

General Comments

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