INT23264

Context Info Confidence 0.39 First Reported 1990 Last Reported 2006 Negated 0 Speculated 1 Reported most in Abstract Documents 16 Total Number 17 Disease Relevance 8.47 Pain Relevance 8.90

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)

Anatomy Link Frequency blood 5 platelet 4 nociceptor 2 microglial cells 2 lung 2 Ptgs1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00 cINOD 31 99.98 Analgesic 10 99.94 COX2 7 99.82 cOX1 4 99.82 Inflammation 24 99.30 nociceptor 1 99.24 licofelone 8 98.68 Limbic system 1 98.68 aspirin 17 98.48

Disease Link Frequency Relevance Heat INFLAMMATION 36 99.86 Pleurisy 8 98.88 Peritonitis 8 98.04 Disease 7 97.64 Rheumatoid Arthritis 10 97.60 Osteoarthritis 3 97.40 Pain 8 96.80 Toxicity 1 95.48 Nociception 2 95.28 Coronary Artery Disease 5 95.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NOAs ("peripheral analgesics") inhibit cyclooxygenase hindering activation of the peripheral nociceptor-system.

Negative_regulation (inhibit) of Positive_regulation (activation) of cyclooxygenase in nociceptor associated with nociceptor and analgesic

1) Confidence 0.39 Published 2000 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 11130128 Disease Relevance 1.09 Pain Relevance 1.92

Experimental, epidemiologic, and clinical studies provide evidence that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the selective cyclooxygenase (COX)-2 inhibitors, including celecoxib and several phytochemicals, act as anticancer agents.

Negative_regulation (inhibitors) of Positive_regulation (selective) of cyclooxygenase associated with inflammation and cinod

2) Confidence 0.37 Published 2005 Journal Curr Gastroenterol Rep Section Abstract Doc Link 16168238 Disease Relevance 0.34 Pain Relevance 0.24

We investigated the inhibitory effect of paracetamol and caffeine on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)- and prostaglandin (PG)E(2)-synthesis in primary rat microglial cells and compared it with the effect of acetylsalicylic acid, salicylic acid, and dipyrone.

Spec (investigated) Negative_regulation (effect) of Positive_regulation (induced) of cyclooxygenase in microglial cells associated with aspirin and paracetamol

3) Confidence 0.24 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10963764 Disease Relevance 0 Pain Relevance 0.85

Non-steroidal anti-inflammatory drugs inhibit constitutive (COX-1) and induced cyclooxygenase (COX-2), blocking prostaglandin production.

Negative_regulation (blocking) of Positive_regulation (induced) of cyclooxygenase associated with inflammation and cinod

4) Confidence 0.21 Published 1998 Journal Neuroreport Section Abstract Doc Link 9559932 Disease Relevance 0.27 Pain Relevance 0.29

Non-steroidal anti-inflammatory drugs inhibit constitutive (COX-1) and induced cyclooxygenase (COX-2), blocking prostaglandin production.

Negative_regulation (inhibit) of Positive_regulation (induced) of cyclooxygenase associated with inflammation and cinod

5) Confidence 0.21 Published 1998 Journal Neuroreport Section Abstract Doc Link 9559932 Disease Relevance 0.27 Pain Relevance 0.29

Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels.

Negative_regulation (suppresses) of Positive_regulation (inducible) of cyclooxygenase in lung associated with cox1

6) Confidence 0.20 Published 2000 Journal Inflamm. Res. Section Title Doc Link 11211925 Disease Relevance 0 Pain Relevance 0.24

Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.

Negative_regulation (inhibits) of Positive_regulation (activation) of cyclooxygenase-1 in platelet associated with licofelone

7) Confidence 0.12 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15044038 Disease Relevance 0.36 Pain Relevance 0.55

This report summarizes studies undertaken to compare meloxicam to other NSAIDs in the inhibition of the inducible cyclooxygenase (COX-2) in inflamed areas (pleurisy of the rat, peritonitis of mice) and their influence on the activity of the constitutive cyclooxygenase (COX-1) in stomach, kidney, brain, and blood.

Negative_regulation (inhibition) of Positive_regulation (inducible) of cyclooxygenase in blood associated with peritonitis, pleurisy and cinod

8) Confidence 0.09 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.53 Pain Relevance 0.39

Aspirin, sulfinpyrazone, and most other nonsteroidal anti-inflammatory agents alter platelet function by inhibiting the activity of cyclooxygenase, an enzyme necessary for the production of prostaglandins.

Negative_regulation (inhibiting) of Positive_regulation (necessary) of cyclooxygenase in platelet associated with aspirin and inflammation

9) Confidence 0.03 Published 1990 Journal Clin Pharm Section Abstract Doc Link 2407421 Disease Relevance 0.49 Pain Relevance 0.12

This report summarizes studies undertaken to compare meloxicam to other NSAIDs in the inhibition of the inducible cyclooxygenase (COX-2) in inflamed areas (pleurisy of the rat, peritonitis of mice) and their influence on the activity of the constitutive cyclooxygenase (COX-1) in stomach, kidney, brain, and blood.

Negative_regulation (inhibition) of in stomach Positive_regulation (inducible) of cyclooxygenase in blood associated with peritonitis, pleurisy and cinod

10) Confidence 0.03 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.53 Pain Relevance 0.39

This report summarizes studies undertaken to compare meloxicam to other NSAIDs in the inhibition of the inducible cyclooxygenase (COX-2) in inflamed areas (pleurisy of the rat, peritonitis of mice) and their influence on the activity of the constitutive cyclooxygenase (COX-1) in stomach, kidney, brain, and blood.

Negative_regulation (inhibition) of in kidney Positive_regulation (inducible) of cyclooxygenase in blood associated with peritonitis, pleurisy and cinod

11) Confidence 0.03 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.53 Pain Relevance 0.39

This report summarizes studies undertaken to compare meloxicam to other NSAIDs in the inhibition of the inducible cyclooxygenase (COX-2) in inflamed areas (pleurisy of the rat, peritonitis of mice) and their influence on the activity of the constitutive cyclooxygenase (COX-1) in stomach, kidney, brain, and blood.

Negative_regulation (inhibition) of in brain Positive_regulation (inducible) of cyclooxygenase in blood associated with peritonitis, pleurisy and cinod

12) Confidence 0.03 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.53 Pain Relevance 0.39

[New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase].

Negative_regulation (inhibitors) of Positive_regulation (inducible) of cyclooxygenase

13) Confidence 0.02 Published 1998 Journal Med. Klin. (Munich) Section Title Doc Link 9711054 Disease Relevance 0.33 Pain Relevance 0.59

Classic NSAIDs inhibit both COX isoenzymes by occupying the cyclooxygenase-active site, preventing access by arachidonic acid.

Negative_regulation (inhibit) of Positive_regulation (occupying) of cyclooxygenase-active site associated with cinod

14) Confidence 0.01 Published 1999 Journal Clin Ther Section Abstract Doc Link 10509845 Disease Relevance 1.11 Pain Relevance 0.85

We reviewed data suggesting the hypothesis that specific inhibition of the inducible isoform of cyclooxygenase, COX-2, would provide therapeutic benefit in patients with rheumatoid arthritis (RA) with less gastrointestinal toxicity and presented the results of a therapeutic trial to test this hypothesis.

Negative_regulation (inhibition) of Positive_regulation (inducible) of cyclooxygenase associated with toxicity and rheumatoid arthritis

15) Confidence 0.01 Published 1997 Journal J Rheumatol Suppl Section Abstract Doc Link 9249645 Disease Relevance 0.44 Pain Relevance 0.28

Development of a new class of drugs designed to selectively inhibit the inducible cyclooxygenase isoenzyme, COX-2, was initially prescribed for individuals diagnosed with osteoarthritis or rheumatoid arthritis.

Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase isoenzyme associated with rheumatoid arthritis and osteoarthritis

16) Confidence 0.01 Published 2003 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 14552698 Disease Relevance 0.73 Pain Relevance 0.66

The classic target of NSAIDs is the prevention of cyclooxygenase (COX) activation.

Negative_regulation (prevention) of Positive_regulation (activation) of cyclooxygenase associated with cinod

17) Confidence 0.01 Published 2006 Journal Ann. Neurol. Section Abstract Doc Link 16402383 Disease Relevance 0.93 Pain Relevance 0.45

General Comments

This test has worked.