INT232831

Context Info Confidence 0.39 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 4.61 Pain Relevance 0.21

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)

Anatomy Link Frequency liver 3 hepatocyte 2 Krt18 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 32 99.52 Potency 4 90.16 COX2 1 46.44 Inflammation 12 38.32 Paracetamol 16 37.76 cytokine 9 27.32 alcohol 15 5.00 Bile 12 5.00 cva 4 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Acute Liver Failure 36 99.76 Cirrhosis 32 99.76 Apoptosis 120 99.52 Liver Disease 60 99.48 Chronic Hepatitis 16 98.00 Targeted Disruption 56 90.96 Gliosis 4 80.64 Disease 70 79.68 Neurodegenerative Disease 8 79.32 Muscle Disease 4 75.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Furthermore, K8/K18 variants associate with liver fibrosis progression in patients with chronic hepatitis C (Strnad et al. 2006).

K18 Binding (associate) of in liver associated with fibrosis, chronic hepatitis and cirrhosis

1) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.90 Pain Relevance 0.08

K8/K18 variants also associate with development of liver fibrosis in patients with chronic hepatitis C.

K18 Binding (associate) of in liver associated with fibrosis, chronic hepatitis and cirrhosis

2) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 1.06 Pain Relevance 0.05

K8/K18 bind to several apoptotic proteins and type I keratins are established caspase substrates (Oshima 2002; Green et al. 2005; Marceau et al. 2007).

K18 Binding (bind) of associated with apoptosis

3) Confidence 0.29 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.09 Pain Relevance 0

Antibodies recognizing the fetal hepatocyte marker cytokeratin 18 (CK18) revealed label-positive cells in PiT1 mutant embryos at E12.5, suggesting that, at least at this stage, developing hepatocytes were present (Fig. 6A and B).

CK18 Binding (recognizing) of in hepatocyte

4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.14 Pain Relevance 0

Several K8/K18 variants were found to associate with the development of cryptogenic liver disease (Ku et al. 2001).

K18 Binding (associate) of in liver associated with liver disease

5) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.99 Pain Relevance 0.07

Antibodies recognizing the fetal hepatocyte marker cytokeratin 18 (CK18) revealed label-positive cells in PiT1 mutant embryos at E12.5, suggesting that, at least at this stage, developing hepatocytes were present (Fig. 6A and B).

cytokeratin 18 Binding (recognizing) of in hepatocyte

6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.14 Pain Relevance 0

Other signatures of up-regulated genes in USC-HN1 cells include ATP5H, HSP27, FABP5, E-cadherin, EIF4G2, KRT18 and KRT8, RPLP0 and RPS18, which are associated with various biological processes such as cell growth and maintenance, cell cycle regulation, metabolism, and protein translation and synthesis (Table 4).

KRT18 Binding (associated) of

7) Confidence 0.09 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.29 Pain Relevance 0

General Comments

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