INT232962

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.38
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18)
cytoplasm (KRT18)
Anatomy Link Frequency
hepatocytes 1
lumen 1
epithelial cells 1
KRT18 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 88 98.56 Very High Very High Very High
Inflammation 34 77.76 Quite High
chemokine 2 75.28 Quite High
Paracetamol 2 56.80 Quite High
medulla 21 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 120 99.96 Very High Very High Very High
Cancer 255 95.24 Very High Very High Very High
Disease 45 92.64 High High
Targeted Disruption 57 90.84 High High
Apoptosis 47 83.68 Quite High
INFLAMMATION 33 77.76 Quite High
Necrosis 6 71.44 Quite High
Death 3 69.56 Quite High
Lung Cancer 18 62.72 Quite High
Carcinoma 66 61.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The classical example is the liver, with K8/K18 representing the characteristic and only keratin pair of normal hepatocytes.
K18 Binding (liver) of in hepatocytes
1) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.26 Pain Relevance 0
K8/K18: primary keratins of simple epithelial cells
K18 Binding (keratins) of in epithelial cells
2) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.99 Pain Relevance 0
Furthermore, K8/K18 occur—together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, K8 and K18 are often most prominent in the lumen-lining cells.
K18 Binding (prominent) of in lumen
3) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
Specific binding to CK8, CK18, and CK19 was noted in the sera of ASA-intolerant asthma subjects.


CK18 Binding (binding) of associated with asthma and aspirin
4) Confidence 0.03 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.42 Pain Relevance 0.05
In isocyanate-induced asthma, CK18 has been identified as a major diisocyanate-binding protein (18), and significantly higher levels of serum IgG to CK19 have been detected (19).
CK18 Binding (binding) of associated with asthma
5) Confidence 0.02 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.71 Pain Relevance 0.13

General Comments

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