INT232962

Context Info Confidence 0.26 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.38 Pain Relevance 0.18

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18) cytoplasm (KRT18)

Anatomy Link Frequency hepatocytes 1 lumen 1 epithelial cells 1 KRT18 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 88 98.56 Inflammation 34 77.76 chemokine 2 75.28 Paracetamol 2 56.80 medulla 21 5.00 cINOD 8 5.00 Chronic pancreatitis 3 5.00 Bile 3 5.00 Potency 3 5.00 corticosteroid 2 5.00

Disease Link Frequency Relevance Heat Asthma 120 99.96 Cancer 255 95.24 Disease 45 92.64 Targeted Disruption 57 90.84 Apoptosis 47 83.68 INFLAMMATION 33 77.76 Necrosis 6 71.44 Death 3 69.56 Lung Cancer 18 62.72 Carcinoma 66 61.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The classical example is the liver, with K8/K18 representing the characteristic and only keratin pair of normal hepatocytes.

K18 Binding (liver) of in hepatocytes

1) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.26 Pain Relevance 0

K8/K18: primary keratins of simple epithelial cells

K18 Binding (keratins) of in epithelial cells

2) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.99 Pain Relevance 0

Furthermore, K8/K18 occur—together with other keratins—in various pseudostratified (e.g. respiratory) and complex (e.g. glandular) epithelia and in the urothelium; in these composite epithelial tissues, K8 and K18 are often most prominent in the lumen-lining cells.

K18 Binding (prominent) of in lumen

3) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0

Specific binding to CK8, CK18, and CK19 was noted in the sera of ASA-intolerant asthma subjects.

CK18 Binding (binding) of associated with asthma and aspirin

4) Confidence 0.03 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.42 Pain Relevance 0.05

In isocyanate-induced asthma, CK18 has been identified as a major diisocyanate-binding protein (18), and significantly higher levels of serum IgG to CK19 have been detected (19).

CK18 Binding (binding) of associated with asthma

5) Confidence 0.02 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.71 Pain Relevance 0.13

General Comments

This test has worked.