INT232969

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KRT5) mitochondrion (KRT5) cytoplasm (KRT5)
Anatomy Link Frequency
skin 2
KRT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 21 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 99.84 Very High Very High Very High
Skin Diseases 6 92.40 High High
Epidermolysis Bullosa Simplex 15 91.88 High High
Cancer 255 75.72 Quite High
Nasopharynx Cancer 6 73.92 Quite High
Metastasis 48 72.00 Quite High
Skin Cancer 87 69.48 Quite High
Injury 36 57.04 Quite High
Lung Cancer 18 54.64 Quite High
Adenocarcinoma 138 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies using specific MAbs—such as MAb 6B10 against K4 (van Muijen et al. 1986) and MAbs 1C7, 2D7 (van Muijen et al. 1986) and Ks13.1 (Moll et al. 1988b) against K13—revealed the presence of K4 and K13 in the entire suprabasal compartment of mucosal stratified squamous epithelia, whereas the basal compartment is positive for K5/K14.
Positive_regulation (positive) of K5
1) Confidence 0.27 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
The functional importance of K5 and K14 for the physical stability of the epidermis has become clearly evident by the recognition that dominant-negative mutations of the K5 or the K14 gene cause the hereditary blistering skin disease epidermolysis bullosa simplex (EBS) (for reviews, see Omary et al. 2004; Lane and McLean 2004).
Positive_regulation (importance) of K5 in skin associated with skin diseases and epidermolysis bullosa simplex
2) Confidence 0.27 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.86 Pain Relevance 0
The mouse K5 promoter is frequently used in transgenic experiments to promote epidermis-specific expression of transgenes (e.g.
Positive_regulation (used) of K5 in epidermis associated with targeted disruption
3) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.32 Pain Relevance 0

General Comments

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