INT233013

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.78
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) intracellular (Parp1)
DNA binding (Parp1) protein complex (Parp1) nucleolus (Parp1)
Parp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 100 99.98 Very High Very High Very High
Inflammatory response 12 95.88 Very High Very High Very High
Inflammation 17 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 24 100.00 Very High Very High Very High
Cv Unclassified Under Development 92 99.98 Very High Very High Very High
INFLAMMATION 29 95.88 Very High Very High Very High
Death 7 94.36 High High
Infarction 2 91.16 High High
Ovarian Cancer 32 60.88 Quite High
Brain Hemorrhage 6 50.00 Quite Low
Cancer 26 5.00 Very Low Very Low Very Low
Stroke 20 5.00 Very Low Very Low Very Low
Body Weight 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experimental conditions, photothrombotic ischemia leads to PARP-1 activation at 4 h and 24 h after the onset of ischemia as evidenced by a marked PAR immunostaining, the enzymatic product of PARP-1 (Fig. 3A).
Positive_regulation (leads) of Positive_regulation (activation) of PARP-1 associated with ischemia
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.65 Pain Relevance 0.28
In our study, the choice of a strategy targeting PARP-1 activation was based on previous studies showing that PARP-1 is also an essential component in the regulation of inflammatory response through its function as a coactivator of NF-?
Positive_regulation (targeting) of Positive_regulation (activation) of PARP-1 associated with inflammatory response
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.58 Pain Relevance 0.20
To define the cellular response of SKOV-3 cells upon Fe-SP treatment we analyzed the activation of caspases characteristic for induction of apoptosis as well as the inactivation of PARP-1 by immunoblotting.
Spec (analyzed) Positive_regulation (activation) of Positive_regulation (induction) of PARP-1 associated with apoptosis
3) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386551 Disease Relevance 0.55 Pain Relevance 0

General Comments

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