INT23309

Context Info Confidence 0.38 First Reported 1985 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0 Pain Relevance 2.88

cell differentiation (INA)

INA (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 82 100.00 sodium channel 6 100.00 local anesthetic 3 87.32 lidocaine 1 69.60 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 4 5.00 Myocardial Infarction 4 5.00 Fibrosis 2 5.00 Hypertension 2 5.00 Hypertrophy 2 5.00 Breast Cancer 2 5.00 Dilated Cardiomyopathy 2 5.00 Cicatrix 2 5.00 Injury 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inactivation of INa.TTX and INa.TTXR was fitted to a monoexponential function with time constant (?)

Negative_regulation (fitted) of Positive_regulation (Inactivation) of INa associated with tetrodotoxin

1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.16

Inactivation of INa.TTX and INa.TTXR was fitted to a monoexponential function with time constant (?)

Negative_regulation (fitted) of Positive_regulation (Inactivation) of INa associated with tetrodotoxin

2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.16

The data obtained provide evidence in favour of the hypothesis about the existence of the different binding sites responsible for cumulative blockade of the INa induced by tertiary and quaternary amines.

Negative_regulation (blockade) of Positive_regulation (induced) of INa associated with sodium channel

3) Confidence 0.37 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2410054 Disease Relevance 0 Pain Relevance 0.55

General Comments

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