INT233102

Context Info Confidence 0.34 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.70 Pain Relevance 2.25

extracellular region (VMO1)

Anatomy Link Frequency knee 1 VMO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 288 100.00 Patellofemoral syndrome 178 98.40 visual analogue scale 9 96.52 Pain score 5 92.52 imagery 2 47.36 ischemia 4 5.00 corticosteroid 2 5.00 Spinal cord 2 5.00 Neuropathic pain 2 5.00 nerve block 2 5.00

Disease Link Frequency Relevance Heat Pain 277 100.00 Patellofemoral Pain Syndrome 194 98.40 Frailty 6 93.24 Congenital Anomalies 12 67.20 Genu Varum 4 64.24 Genu Valgum 4 63.28 Foot Deformities 2 62.24 Flatfoot 2 61.04 Stress 20 21.92 Injury 27 9.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However the influence of higher levels of pain during testing on VMO-VL results was not supported by Brindle et al's [21] study, in which only slightly lower VAS scores were recorded actually during testing, and where there was little difference between the groups in the opposite direction.

Regulation (influence) of VMO-VL associated with pain and visual analogue scale

1) Confidence 0.34 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.69 Pain Relevance 0.82

However, as stated previously, this should have relatively little effect on the relative activation times of VMO and VL, the focus of this review.

Neg (little) Regulation (effect) of VMO

2) Confidence 0.34 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.23 Pain Relevance 0.23

The authors concluded that an altered VMO/VL response time was a risk factor for PFPS [39].

Regulation (altered) of VMO associated with patellofemoral syndrome

3) Confidence 0.27 Published 2008 Journal Dyn Med Section Body Doc Link PMC2443365 Disease Relevance 1.02 Pain Relevance 0.71

Altered VMO muscle reflex time compared to VL is assessed by simultaneous VMO and VL palpation during knee extension.

Regulation (Altered) of VMO in knee

4) Confidence 0.23 Published 2008 Journal Dyn Med Section Body Doc Link PMC2443365 Disease Relevance 0.41 Pain Relevance 0.15

Some studies have demonstrated alterations in VMO-VL onset times in AKP patients following or during successful therapeutic interventions.

Regulation (alterations) of VMO-VL associated with pain

5) Confidence 0.18 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.35 Pain Relevance 0.35

General Comments

This test has worked.