INT233253

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.34
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb3) plasma membrane (Itgb3)
Anatomy Link Frequency
uterine 4
Itgb3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 85.68 High High
cva 7 48.00 Quite Low
endometriosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 7 86.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 85.92 High High
Dislocations 7 85.00 Quite High
Cancer 21 83.08 Quite High
Anaemia 7 49.16 Quite Low
Hemorrhage 7 48.00 Quite Low
Leukemia 35 43.08 Quite Low
Myeloid Leukemia 7 33.00 Quite Low
Acute Myeloid Leukemia 28 28.64 Quite Low
Hypersensitivity 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate a possible connection between Meis1 and Hoxa10 function in murine uterine development and embryonic implantation, we evaluated the effect of Meis1 expression manipulation on Itgb3 expression.
Regulation (effect) of Gene_expression (expression) of Itgb3 in uterine
1) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
To elucidate potential mechanisms by which Meis1 might control endometrial function and receptivity to the implanting blastocyst, we tested the effect of altering Meis1 expression on Itgb3 expression.
Regulation (effect) of Gene_expression (expression) of Itgb3
2) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
The expression pattern of MEIS1, its contribution to pinopode formation in mouse and its effect on Itgb3 expression suggest that the effects of MEIS1 on endometrial function occur through affecting the affinity and specificity of HOXA10–DNA interactions, leading to the regulation of downstream targets of HOXA10.
Regulation (effect) of Gene_expression (expression) of Itgb3
3) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.17 Pain Relevance 0
For the experiments studying the effect of MEIS1 expression manipulation on Itgb3 expression, 25 mice each were transfected with pcDNA4/MEIS1, empty pcDNA4, pTER/Meis1 siRNA construct or non-targeting pTER, respectively (100 mice in total).
Regulation (effect) of Gene_expression (expression) of Itgb3
4) Confidence 0.30 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0.09
HOXA10 has been demonstrated to be involved in the regulation of pinopode development and expression of other genes involved in endometrial development such as ITGB3 and EMX2 (Bagot et al., 2001; Daftary et al., 2002; Troy et al., 2003).
Regulation (regulation) of Gene_expression (expression) of ITGB3
5) Confidence 0.30 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
To elucidate potential mechanisms by which Meis1 might control endometrial function and receptivity to the implanting blastocyst, we tested the effect of altering Meis1 expression on Itgb3 expression.
Regulation (altering) of Gene_expression (expression) of Itgb3
6) Confidence 0.18 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Together, these results showed that, in a murine uterine receptivity model, the expression of the known Hoxa10 target Itgb3 could be regulated by the manipulation of Meis1 expression, suggesting Meis1 action through co-operation, or possibly interaction, with Hoxa10.


Regulation (regulated) of Gene_expression (expression) of Itgb3 in uterine
7) Confidence 0.18 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0

General Comments

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