INT233330

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.46
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEFTY2) extracellular region (LEFTY2)
Anatomy Link Frequency
hepatocyte 1
NK cells 1
LEFTY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 99.04 Very High Very High Very High
cytokine 14 98.16 Very High Very High Very High
fibrosis 17 97.20 Very High Very High Very High
colic 2 89.92 High High
adenocard 1 84.52 Quite High
tolerance 2 84.16 Quite High
alcohol 2 61.76 Quite High
Pain 13 28.32 Quite Low
Endep 1 22.88 Low Low
Paracetamol 1 22.16 Low Low
Disease Link Frequency Relevance Heat
Necrosis 4 99.08 Very High Very High Very High
INFLAMMATION 24 99.04 Very High Very High Very High
Cancer 9 98.72 Very High Very High Very High
Localized Scleroderma 28 98.28 Very High Very High Very High
Fibrosis 16 97.20 Very High Very High Very High
Death 4 94.16 High High
Abdominal Cramps 2 89.92 High High
Fatigue 4 87.36 High High
Keloid Scars 1 84.64 Quite High
Telangiectasia 6 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects could also be due to secreted factors such as transforming growth factor beta, hepatocyte growth factor, prostoglandin E2, and IDO [62] and in some areas, different from MSC effects.
Localization (secreted) of transforming growth factor beta in hepatocyte
1) Confidence 0.15 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2968415 Disease Relevance 0.25 Pain Relevance 0.08
, interleukin-8 (IL-8) and IL-10 also increase and become involved in inflammatory processes and the development of <span style="background-color:#FFA07A">fibrosis</span> [6].
Localization (increase) of transforming growth factor-beta associated with fibrosis and inflammation
2) Confidence 0.07 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2861069 Disease Relevance 1.73 Pain Relevance 0.39
The pathophysiology of RIM is thought to be radiation-induced neoantigen formation that subsequently stimulates secretion of transforming growth factor beta (TGF-?).
Localization (secretion) of transforming growth factor beta associated with localized scleroderma
3) Confidence 0.05 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2390574 Disease Relevance 2.16 Pain Relevance 0.36
Sotiropolou et al. [79] suggested a combinatorial effect on the suppressed proliferation of NK cells via cell-cell contact between MSCs-NK cells and secretion of soluble factors by MSCs including transforming growth factor beta (TGF-?)
Localization (secretion) of transforming growth factor beta in NK cells
4) Confidence 0.05 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

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