INT233330

Context Info Confidence 0.15 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 4.46 Pain Relevance 0.99

extracellular space (LEFTY2) extracellular region (LEFTY2)

Anatomy Link Frequency hepatocyte 1 NK cells 1 LEFTY2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 22 99.04 cytokine 14 98.16 fibrosis 17 97.20 colic 2 89.92 adenocard 1 84.52 tolerance 2 84.16 alcohol 2 61.76 Pain 13 28.32 Endep 1 22.88 Paracetamol 1 22.16

Disease Link Frequency Relevance Heat Necrosis 4 99.08 INFLAMMATION 24 99.04 Cancer 9 98.72 Localized Scleroderma 28 98.28 Fibrosis 16 97.20 Death 4 94.16 Abdominal Cramps 2 89.92 Fatigue 4 87.36 Keloid Scars 1 84.64 Telangiectasia 6 83.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These effects could also be due to secreted factors such as transforming growth factor beta, hepatocyte growth factor, prostoglandin E2, and IDO [62] and in some areas, different from MSC effects.

Localization (secreted) of transforming growth factor beta in hepatocyte

1) Confidence 0.15 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2968415 Disease Relevance 0.25 Pain Relevance 0.08

, interleukin-8 (IL-8) and IL-10 also increase and become involved in inflammatory processes and the development of <span style="background-color:#FFA07A">fibrosis</span> [6].

Localization (increase) of transforming growth factor-beta associated with fibrosis and inflammation

2) Confidence 0.07 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2861069 Disease Relevance 1.73 Pain Relevance 0.39

The pathophysiology of RIM is thought to be radiation-induced neoantigen formation that subsequently stimulates secretion of transforming growth factor beta (TGF-?).

Localization (secretion) of transforming growth factor beta associated with localized scleroderma

3) Confidence 0.05 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2390574 Disease Relevance 2.16 Pain Relevance 0.36

Sotiropolou et al. [79] suggested a combinatorial effect on the suppressed proliferation of NK cells via cell-cell contact between MSCs-NK cells and secretion of soluble factors by MSCs including transforming growth factor beta (TGF-?)

Localization (secretion) of transforming growth factor beta in NK cells

4) Confidence 0.05 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962904 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

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