INT233331

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 2.17 Pain Relevance 0.36

extracellular space (LEFTY2) extracellular region (LEFTY2)

LEFTY2 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 9 92.24 Inflammation 4 90.64 Pain 4 24.80 Endep 1 23.32 Paracetamol 1 22.60 methotrexate 1 15.44 cytokine 1 5.00 pruritus 1 5.00

Disease Link Frequency Relevance Heat Localized Scleroderma 28 98.50 Fibrosis 8 94.20 INFLAMMATION 4 90.64 Keloid Scars 1 85.08 Telangiectasia 6 83.92 Pulmonary Fibrosis 1 79.60 Breast Cancer 8 78.24 Systemic Sclerosis 2 72.64 Endometriosis (extended) 1 67.12 Recurrence 5 45.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The pathophysiology of RIM is thought to be radiation-induced neoantigen formation that subsequently stimulates secretion of transforming growth factor beta (TGF-?).

Positive_regulation (stimulates) of Localization (secretion) of transforming growth factor beta associated with localized scleroderma

1) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2390574 Disease Relevance 2.17 Pain Relevance 0.36

General Comments

This test has worked.