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Context Info
Confidence 0.38
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.02
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf2) extracellular region (Serpinf2)
Anatomy Link Frequency
plasma 1
radial 1
Serpinf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 87.40 High High
medulla 2 82.56 Quite High
Angina 4 75.00 Quite High
Restless leg syndrome 3 75.00 Quite High
abdominal pain 1 52.16 Quite High
pain labor 1 28.56 Quite Low
cytokine 1 25.00 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 5 93.60 High High
Threatened Abortion 1 92.76 High High
Hemorrhage 2 89.68 High High
Disorder Of Lipid Metabolism 1 89.32 High High
Suicidal Behaviour 1 88.04 High High
Sudden Death 6 88.00 High High
Pain 2 87.40 High High
Pressure And Volume Under Development 2 86.92 High High
Atherosclerosis 2 85.68 High High
Injury 3 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of intramedullary haematoma associated with congenital alpha2-plasmin inhibitor deficiency.
Negative_regulation (deficiency) of alpha2-plasmin
1) Confidence 0.38 Published 1998 Journal Pediatr Radiol Section Title Doc Link 9880645 Disease Relevance 0.35 Pain Relevance 0.13
The association of intramedullary haematoma of the left femoral diaphysis and congenital alpha2-plasmin inhibitor deficiency in a 6-year-old boy is reported.
Negative_regulation (deficiency) of alpha2-plasmin
2) Confidence 0.32 Published 1998 Journal Pediatr Radiol Section Abstract Doc Link 9880645 Disease Relevance 0.34 Pain Relevance 0.12
Many inhibitors of the coagulation and fibrinolytic cascades belong to the serpin family, including antithrombin, heparin cofactor 2, plasminogen activator inhibitor PAI-1 and 2, alpha-2 plasmin inhibitor, and PCI (Rau et al. 2007).
Negative_regulation (inhibitor) of alpha-2 plasmin
3) Confidence 0.08 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.09 Pain Relevance 0
Hemostatic factors included fibrinogen, fibrinopeptide A, antithrombin III, factor VIII antigen, factor VIII coagulant, protein C, plasminogen, alpha 2 antiplasmin, euglobulin clot lysis time, tissue plasminogen activator before and after venous occlusion, and plasminogen activator inhibitor.
Negative_regulation (inhibitor) of alpha 2 antiplasmin
4) Confidence 0.03 Published 1995 Journal Am. J. Cardiol. Section Abstract Doc Link 7618616 Disease Relevance 1.29 Pain Relevance 0.14
Significantly lower levels of alpha 2-plasmin inhibitor and higher levels of alpha 2-plasmin inhibitor/plasmin complex and thrombin/antithrombin III complex were found in the patients vs the controls.
Negative_regulation (inhibitor) of alpha 2-plasmin
5) Confidence 0.02 Published 1996 Journal Angiology Section Abstract Doc Link 8678328 Disease Relevance 0.22 Pain Relevance 0.21
At the same time, individual fibrinolytic inhibitors (alpha 2-plasmin inhibitor, alpha 1-antitrypsin, alpha 2-macroglobulin, antithrombin-III, and Cl-inactivator) were determined by the radial immunodiffusion method.
Negative_regulation (inhibitor) of alpha 2-plasmin in radial
6) Confidence 0.02 Published 1981 Journal Int J Biol Res Pregnancy Section Abstract Doc Link 6916725 Disease Relevance 0.15 Pain Relevance 0
In these patients the following substances in plasma were determined: Prekallikrein, alpha 2-plasmin inhibitor, alpha 1-antitrypsin, alpha 2-macroglobulin, C1-inactivator, antithrombin-III, plasminogen, fibrinogen, fibrin degradation products (FDP).
Negative_regulation (inhibitor) of alpha 2-plasmin in plasma
7) Confidence 0.01 Published 1985 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 2411832 Disease Relevance 0.51 Pain Relevance 0.05
The binding of plasminogen to fibrin is regulated by histidine-rich glycoprotein, and the primary physiological inhibitor of generated plasmin is alpha 2-antiplasmin and especially the plasminogen-binding form of this immediate plasmin inhibitor.
Negative_regulation (inhibitor) of alpha 2-antiplasmin
8) Confidence 0.01 Published 1993 Journal Dan Med Bull Section Abstract Doc Link 8222763 Disease Relevance 0.07 Pain Relevance 0

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